{"id":"W3135181020","doi":"10.1007/s40744-021-00294-z","title":"Patient-Reported Outcomes from a Phase 4, Multicenter, Randomized, Double-Blind, Placebo-Controlled Trial of Repository Corticotropin Injection (Acthar® Gel) for Persistently Active Systemic Lupus Erythematosus","year":2021,"lang":"en","type":"article","venue":"Rheumatology and Therapy","topic":"Systemic Lupus Erythematosus Research","field":"Medicine","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Galderma; Mallinckrodt Pharmaceuticals","keywords":"Medicine; Placebo; Systemic lupus erythematosus; Internal medicine; Post-hoc analysis; Prednisone; Adverse effect; Rheumatology; Lupus erythematosus; Rash; Quality of life (healthcare); Immunology; Disease; Pathology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004732189,0.0003805333,0.003138993,0.0002596982,0.0001837196,0.00003462541,0.0001022973,0.0003844317,0.00006054629],"category_scores_gemma":[0.0008284149,0.0002757907,0.0008089247,0.0001580852,0.0002908256,0.0001110131,0.00004563219,0.0002766209,0.000003291743],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001161286,"about_ca_system_score_gemma":0.0004117343,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002591126,"about_ca_topic_score_gemma":0.00001030743,"domain_scores_codex":[0.9958431,0.000835321,0.00180548,0.0006504508,0.0004485,0.0004172251],"domain_scores_gemma":[0.9946612,0.002680046,0.001217263,0.0006016793,0.0006526139,0.000187211],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9551294,0.001786621,0.02450462,0.0004840466,0.00683747,0.0001302543,0.004693508,0.000001427254,0.005395255,0.0001552783,0.00004984721,0.0008322261],"study_design_scores_gemma":[0.9621629,0.001260333,0.00001106848,0.0007196143,0.0006629316,0.02257398,0.004671948,0.0007292934,0.006880272,0.00008551186,0.00003439014,0.0002077885],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9774361,0.007231428,0.0004723186,0.0001661003,0.002365323,0.01202799,0.00002861861,0.00007882337,0.000193277],"genre_scores_gemma":[0.994486,0.001986895,0.000216109,0.00005088375,0.00005001074,0.00267179,0.000100497,0.0000524416,0.0003853527],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02449355,"threshold_uncertainty_score":0.9999694,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03281445817817048,"score_gpt":0.3216902380331188,"score_spread":0.2888757798549483,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}