{"id":"W3135181020","doi":"10.1007/s40744-021-00294-z","title":"Patient-Reported Outcomes from a Phase 4, Multicenter, Randomized, Double-Blind, Placebo-Controlled Trial of Repository Corticotropin Injection (Acthar® Gel) for Persistently Active Systemic Lupus Erythematosus","year":2021,"lang":"en","type":"article","venue":"Rheumatology and Therapy","topic":"Systemic Lupus Erythematosus Research","field":"Medicine","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Galderma; Mallinckrodt Pharmaceuticals","keywords":"Medicine; Placebo; Systemic lupus erythematosus; Internal medicine; Post-hoc analysis; Prednisone; Adverse effect; Rheumatology; Lupus erythematosus; Rash; Quality of life (healthcare); Immunology; Disease; Pathology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002139918,0.001862822,0.002973228,0.0004280591,0.0004830051,0.001034307,0.000847525,0.001937875,0.007282921],"category_scores_gemma":[0.002228674,0.0005961458,0.001807937,0.0003865853,0.0008895756,0.0008742769,0.0003741475,0.003197867,0.0008116238],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005831267,"about_ca_system_score_gemma":0.0008752134,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006337578,"about_ca_topic_score_gemma":0.001298515,"domain_scores_codex":[0.9990594,0.0005160247,0.00006984002,0.000153065,0.00007606039,0.0001256996],"domain_scores_gemma":[0.9985409,0.0004420557,0.000494985,0.00006857001,0.0001126079,0.0003409075],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9824718,0.004620749,0.0006909358,0.0008287411,0.001324044,0.00002948894,0.00003155553,0.0002327459,0.001506158,0.00003893969,0.0006278907,0.007597033],"study_design_scores_gemma":[0.9592532,0.03666427,0.002584689,0.00003315368,0.0007064513,0.00002052345,0.00001160237,0.0001842346,0.0002158566,0.00004570729,0.0002696608,0.00001047117],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9833344,0.007528141,0.000407052,0.0005858394,0.0003636483,0.003321229,0.002211977,0.0001036795,0.002144109],"genre_scores_gemma":[0.9861422,0.00282137,0.001094604,0.0009921013,0.000429633,0.004769613,0.001875602,0.00001983753,0.001854928],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007282921,"threshold_uncertainty_score":0.02436376,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03281445817817048,"score_gpt":0.3216902380331188,"score_spread":0.2888757798549483,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}