{"id":"W3135196082","doi":"10.7554/elife.53036.sa1","title":"Decision letter: Antagonism of PP2A is an independent and conserved function of HIV-1 Vif and causes cell cycle arrest","year":2019,"lang":"en","type":"peer-review","venue":"","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"","keywords":"APOBEC3G; Protein phosphatase 2; Ubiquitin ligase; Biology; Ubiquitin; Cell biology; Antagonism; Genetics; Phosphatase; Cytidine deaminase; DNA; Receptor; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004414408,0.000523362,0.001341697,0.0009278958,0.002461737,0.004554702,0.002064151,0.01720431,0.07674982],"category_scores_gemma":[0.0387399,0.000477371,0.0009953888,0.0006160802,0.001293486,0.002115272,0.001292882,0.008499324,0.05811658],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002334363,"about_ca_system_score_gemma":0.00465471,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002323527,"about_ca_topic_score_gemma":0.005907248,"domain_scores_codex":[0.995865,0.0005521679,0.0004900178,0.0003766345,0.002067755,0.0006483201],"domain_scores_gemma":[0.979741,0.004664036,0.0007165209,0.001016733,0.009541526,0.004320238],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00007453243,0.00002733563,0.00009102151,0.0000585923,0.000006558532,0.0002379637,0.00001373245,0.00002460403,0.0001764522,0.0009990677,0.9911267,0.007163505],"study_design_scores_gemma":[0.00007341181,0.0000421503,0.0007448894,0.0001030983,0.00001016294,0.0002163795,0.00004621012,0.0003570833,0.0004682147,0.001678687,0.9962379,0.00002189091],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"other","genre_scores_codex":[0.001870378,0.001099993,0.001027458,0.5173069,0.4199083,0.0004603061,0.001738967,0.0006942743,0.05589334],"genre_scores_gemma":[0.02883518,0.002891252,0.002695588,0.3210983,0.1992903,0.0004492013,0.001517223,0.0007231108,0.4424998],"genre_candidate":"other","genre_consensus":null,"teacher_disagreement_score":0.07674982,"threshold_uncertainty_score":0.2567537,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02458434897319218,"score_gpt":0.2859064182611878,"score_spread":0.2613220692879956,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}