{"id":"W3135210775","doi":"10.1089/hum.2020.292","title":"The Engineered MARCH8-Resistant Vesicular Stomatitis Virus Glycoprotein Enhances Lentiviral Vector Transduction","year":2021,"lang":"en","type":"article","venue":"Human Gene Therapy","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Jewish General Hospital","funders":"Canadian Institutes of Health Research","keywords":"Vesicular stomatitis virus; Transduction (biophysics); Viral vector; Biology; Ubiquitin ligase; Virology; Genetic enhancement; Gene delivery; Virus; Ubiquitin; Cell biology; Molecular biology; Gene; Genetics; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004016762,0.0002573751,0.000194838,0.00004509905,0.0005128934,0.0001221024,0.0003873361,0.0001256615,0.0003044662],"category_scores_gemma":[0.00001671939,0.0002129859,0.0002072054,0.0001774798,0.0001714148,0.00000843417,0.00004949225,0.0001699241,0.00003052326],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003987949,"about_ca_system_score_gemma":0.0001541388,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003682315,"about_ca_topic_score_gemma":0.0008262888,"domain_scores_codex":[0.9979995,0.0003534096,0.0002827809,0.0004997728,0.0003817859,0.0004827161],"domain_scores_gemma":[0.9989054,0.00001812293,0.0000704613,0.0007626686,0.0001504975,0.00009281248],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001240612,0.0001009187,0.000006608803,0.000009898035,0.0002177408,0.0000245617,0.00009735821,0.00002920379,0.9815407,0.00007931451,0.0004131785,0.0162399],"study_design_scores_gemma":[0.001073385,0.001772731,0.0008690591,0.000009786733,0.000008366756,0.00001568746,0.00004988023,0.00001458972,0.9680407,0.000235035,0.0276536,0.0002571532],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9804597,0.01791425,0.0004029561,0.0003616543,0.0001983682,0.0003976814,0.00003300412,0.00004087688,0.000191434],"genre_scores_gemma":[0.9906328,0.006019874,0.0001816388,0.0001453751,0.0006026759,0.0001738533,0.0001825004,0.00006773474,0.001993553],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02724042,"threshold_uncertainty_score":0.8685313,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0170430874006768,"score_gpt":0.2775879909138775,"score_spread":0.2605449035132007,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}