{"id":"W3135210775","doi":"10.1089/hum.2020.292","title":"The Engineered MARCH8-Resistant Vesicular Stomatitis Virus Glycoprotein Enhances Lentiviral Vector Transduction","year":2021,"lang":"en","type":"article","venue":"Human Gene Therapy","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Jewish General Hospital","funders":"Canadian Institutes of Health Research","keywords":"Vesicular stomatitis virus; Transduction (biophysics); Viral vector; Biology; Ubiquitin ligase; Virology; Genetic enhancement; Gene delivery; Virus; Ubiquitin; Cell biology; Molecular biology; Gene; Genetics; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001510244,0.0004058167,0.0002768787,0.0002169806,0.0001219166,0.0002932576,0.0003251719,0.0004616195,0.000707612],"category_scores_gemma":[0.0001102636,0.0001579183,0.0002996015,0.0001496358,0.0002165544,0.0001904672,0.0002650579,0.0005635574,0.0003645392],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000345951,"about_ca_system_score_gemma":0.0001610765,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003125085,"about_ca_topic_score_gemma":0.0003359858,"domain_scores_codex":[0.9998786,0.00001665095,0.0000152703,0.00002824634,0.00003939755,0.00002168423],"domain_scores_gemma":[0.9999359,0.00000768765,0.00002530187,0.000008948431,0.000007986461,0.00001419406],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000288246,0.000009354382,0.00006773391,0.00001451654,0.00000309878,0.00004157168,0.000005660203,0.00007332503,0.9986634,0.0001842535,0.00002489919,0.0008832748],"study_design_scores_gemma":[0.00001193865,0.0001006861,0.0005522872,0.000002753098,0.00001358043,0.0003408318,0.000004884421,0.001218857,0.9939038,0.00006145939,0.003783411,0.000005341285],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9740463,0.0008685786,0.02198463,0.0001225851,0.00006173379,0.0001103739,0.0004367271,0.0003647326,0.002004096],"genre_scores_gemma":[0.975491,0.0006221497,0.01845973,0.00005746757,0.00001458511,0.00006708901,0.0006278476,0.00005443838,0.004605847],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000707612,"threshold_uncertainty_score":0.002510011,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0170430874006768,"score_gpt":0.2775879909138775,"score_spread":0.2605449035132007,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}