{"id":"W3135212690","doi":"10.1093/jcag/gwab002.051","title":"A53 STUDYING THE ROLE OF ASCL2 IN THE ESOPHAGEAL EPITHELIUM USING ORGANOIDS","year":2021,"lang":"en","type":"article","venue":"Journal of the Canadian Association of Gastroenterology","topic":"Cancer-related gene regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke","funders":"","keywords":"Organoid; LGR5; Stem cell; Wnt signaling pathway; Cell biology; Biology; Population; Notch signaling pathway; Cancer research; Cancer stem cell; Medicine; Signal transduction","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000268956,0.0003378607,0.0003420338,0.000387049,0.0003105267,0.0004319696,0.0002730047,0.0004527641,0.001911948],"category_scores_gemma":[0.0001186045,0.0001699928,0.0006006397,0.0002708141,0.0002382914,0.0002919245,0.0003605881,0.0009377492,0.001079292],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003806654,"about_ca_system_score_gemma":0.0002162065,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009488558,"about_ca_topic_score_gemma":0.0009840506,"domain_scores_codex":[0.9997703,0.0000334618,0.00002463852,0.00006575538,0.00007641548,0.00002942423],"domain_scores_gemma":[0.9998047,0.00003280076,0.00002720607,0.00004817617,0.00003159796,0.00005559249],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007910426,0.0000261776,0.0003439496,0.00006994168,0.000007393554,0.0001570926,0.00004441412,0.0002779973,0.9974945,0.0001672768,0.0001233683,0.001208861],"study_design_scores_gemma":[0.00001125115,0.0002749972,0.002552803,0.00001484639,0.00002524718,0.0003505647,0.0001023107,0.002621487,0.9869161,0.00009180785,0.007030173,0.000008370915],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9455396,0.003773657,0.03641647,0.0002868541,0.0002062595,0.0002012648,0.004484887,0.0005965692,0.008494514],"genre_scores_gemma":[0.9754325,0.0010899,0.01062647,0.00009455458,0.00001023475,0.0002149163,0.002535998,0.0000643137,0.009931005],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001911948,"threshold_uncertainty_score":0.006396055,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006297193776312,"score_gpt":0.2185626280934117,"score_spread":0.2122654343170997,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}