{"id":"W3135230498","doi":"10.1158/1538-7445.tme21-lt015","title":"Abstract LT015: Overcoming chemotherapy resistance in triple negative breast cancer <i>via</i> targeting lysyl oxidase (LOX)","year":2021,"lang":"en","type":"article","venue":"Cancer Research","topic":"Microbial metabolism and enzyme function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"Lysyl oxidase; Cancer research; Doxorubicin; Triple-negative breast cancer; Kinome; Biology; Breast cancer; Chemistry; Cancer; Medicine; Chemotherapy; Kinase; Extracellular matrix; Cell biology; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006747911,0.0001679442,0.0002149573,0.0000850669,0.0001694571,0.00004945015,0.000203468,0.0001652759,0.0006808696],"category_scores_gemma":[0.0001596833,0.0001714074,0.0000815538,0.0005327689,0.0001086101,0.00001757818,0.0001121051,0.0003935165,0.00001290274],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001515488,"about_ca_system_score_gemma":0.0005014983,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001976338,"about_ca_topic_score_gemma":0.004947476,"domain_scores_codex":[0.9980884,0.0001809166,0.0002655068,0.0005873332,0.00029743,0.0005804708],"domain_scores_gemma":[0.9990308,0.00003722459,0.00006789956,0.0003309276,0.000416456,0.0001166946],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005706787,0.00006631418,0.0009472508,0.00007289495,0.00003265577,0.00001698073,0.0001656174,0.00004573076,0.9492061,0.00001641635,0.04487123,0.003988129],"study_design_scores_gemma":[0.00144829,0.00001517228,0.01245026,0.000124204,0.000004965081,0.000003782322,0.0001755872,0.000007448178,0.8847301,0.0001129058,0.1007088,0.0002184492],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9828036,0.01342438,0.00008849537,0.001815352,0.0004136727,0.0002582331,0.0002547573,0.00001200234,0.000929469],"genre_scores_gemma":[0.9860419,0.007079237,0.000326072,0.0005885368,0.001135834,0.0001734242,0.00007749232,0.00004955721,0.004527918],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06447598,"threshold_uncertainty_score":0.7455044,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02256478237997956,"score_gpt":0.3277638275673069,"score_spread":0.3051990451873273,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}