{"id":"W3135236000","doi":"10.3390/cells10030568","title":"Generation and Evaluation of Isogenic iPSC as a Source of Cell Replacement Therapies in Patients with Kearns Sayre Syndrome","year":2021,"lang":"en","type":"article","venue":"Cells","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; St. Boniface Hospital","funders":"Canadian Institutes of Health Research","keywords":"Induced pluripotent stem cell; Mitochondrial DNA; Peripheral blood mononuclear cell; Progenitor cell; Biology; Stem cell; Mitochondrion; Myocyte; Kearns–Sayre syndrome; Mutation; Cancer research; Cell biology; Medicine; Genetics; Embryonic stem cell; Gene; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001498095,0.00005419384,0.00008568051,0.0000236312,0.00001226178,0.000003155588,0.00002330709,0.00006184893,0.0001132886],"category_scores_gemma":[0.0000154826,0.00004868369,0.00001848245,0.00004859058,0.0000237257,0.000001779667,0.00002039982,0.0000251597,0.00000183453],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000005952333,"about_ca_system_score_gemma":0.00006183905,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000009340563,"about_ca_topic_score_gemma":0.00002706601,"domain_scores_codex":[0.9994112,0.0001243437,0.0001297806,0.0001609436,0.0001167084,0.00005703744],"domain_scores_gemma":[0.9996036,0.00000466203,0.00007521975,0.0001508729,0.000149391,0.00001627569],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001056348,0.0000935828,0.01212706,0.00001532735,0.00001678572,4.283282e-7,0.0002043959,0.0003256087,0.9864769,0.000004113927,0.00009276215,0.0005373755],"study_design_scores_gemma":[0.001800677,0.000764618,0.01317044,0.000009433856,0.00003213555,0.000003934008,0.0001400878,0.0001384747,0.9829665,0.00000921189,0.0008955006,0.00006899332],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9987718,0.0004620149,0.0002046849,0.00001184291,0.00008331839,0.0001590602,0.000003786164,0.000001035732,0.0003024882],"genre_scores_gemma":[0.9987723,0.00005969168,0.0002898713,0.00004381877,0.00001700042,0.000007912716,0.0001074353,0.000005842678,0.0006961214],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003510432,"threshold_uncertainty_score":0.1985263,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01411269491957467,"score_gpt":0.2356576203092545,"score_spread":0.2215449253896798,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}