{"id":"W3135236000","doi":"10.3390/cells10030568","title":"Generation and Evaluation of Isogenic iPSC as a Source of Cell Replacement Therapies in Patients with Kearns Sayre Syndrome","year":2021,"lang":"en","type":"article","venue":"Cells","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; St. Boniface Hospital","funders":"Canadian Institutes of Health Research","keywords":"Induced pluripotent stem cell; Mitochondrial DNA; Peripheral blood mononuclear cell; Progenitor cell; Biology; Stem cell; Mitochondrion; Myocyte; Kearns–Sayre syndrome; Mutation; Cancer research; Cell biology; Medicine; Genetics; Embryonic stem cell; Gene; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005234954,0.0002668343,0.0005711504,0.0003835723,0.0002400407,0.000406739,0.0002872049,0.000507474,0.0007714222],"category_scores_gemma":[0.0003889472,0.0001091282,0.0003520754,0.0002317209,0.0002616819,0.0001840199,0.000232764,0.0005760544,0.0002765597],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001320649,"about_ca_system_score_gemma":0.0001664603,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001928532,"about_ca_topic_score_gemma":0.0001764247,"domain_scores_codex":[0.999606,0.00008893426,0.00007199286,0.00007606311,0.0001280747,0.00002898468],"domain_scores_gemma":[0.999881,0.0000243795,0.00001746822,0.00002096716,0.00002798357,0.00002804252],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001085414,0.001170155,0.006221958,0.000312211,0.00008695936,0.003654736,0.0005504228,0.0008289316,0.9479169,0.0004001321,0.0003961695,0.03737605],"study_design_scores_gemma":[0.0007747101,0.02455859,0.05035939,0.0001335261,0.000802368,0.02412051,0.0008083072,0.004504334,0.8713741,0.0005007008,0.0219934,0.00006999977],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9928397,0.003046821,0.002502954,0.0001156043,0.00004499308,0.0001468047,0.0002023701,0.00003459243,0.001066132],"genre_scores_gemma":[0.9937299,0.002255627,0.002177058,0.0001736641,0.0000253952,0.0001862936,0.0007535273,0.00001442174,0.0006841565],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007714222,"threshold_uncertainty_score":0.002768517,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01411269491957467,"score_gpt":0.2356576203092545,"score_spread":0.2215449253896798,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}