{"id":"W3135248026","doi":"10.1200/jco.2021.39.6_suppl.463","title":"Heterogeneity in Nectin-4 expression across molecular subtypes of urothelial cancer mediates sensitivity to enfortumab vedotin.","year":2021,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Bladder and Urothelial Cancer Treatments","field":"Medicine","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; Genome British Columbia","funders":"","keywords":"Bladder cancer; Medicine; Cancer; Cancer research; FOXA1; Internal medicine; GATA3; Oncology; Biology; Breast cancer; Gene; Transcription factor; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003033147,0.0001249527,0.0002899236,0.0002919089,0.000167329,0.000392385,0.0001798966,0.0002304593,0.0007387273],"category_scores_gemma":[0.0006849474,0.0001383231,0.0002348186,0.0002964917,0.0002263696,0.0002015982,0.0002684434,0.0002426216,0.0001729626],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002869093,"about_ca_system_score_gemma":0.0001525312,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008944362,"about_ca_topic_score_gemma":0.001127611,"domain_scores_codex":[0.9997665,0.00005212977,0.0000240641,0.00006399108,0.00004503795,0.00004820494],"domain_scores_gemma":[0.999615,0.0001055949,0.0001443711,0.00004950869,0.00003861772,0.0000469332],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001143774,0.0000563042,0.5692523,0.0001451943,0.0001659002,0.000374297,0.000253369,0.0004400709,0.4158575,0.00009382983,0.0001830312,0.0120345],"study_design_scores_gemma":[0.00001435126,0.0003880947,0.9441745,0.00001075263,0.000101279,0.001959274,0.0002533454,0.0009642629,0.05119763,0.00008391823,0.0008455871,0.000006961589],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9992945,0.0002834358,0.0001526593,0.00001022649,7.68984e-7,0.000003894122,0.00009589009,0.000004753084,0.0001539573],"genre_scores_gemma":[0.9994381,0.00008169327,0.0001190925,0.000009950892,0.000001239944,0.000005261534,0.0002555208,0.000002783098,0.00008631969],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008944362,"threshold_uncertainty_score":0.002471328,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09092638528811434,"score_gpt":0.4885105235147176,"score_spread":0.3975841382266032,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}