{"id":"W3135273387","doi":"10.1002/etc.5032","title":"In Vitro Screening of 21 Bisphenol A Replacement Alternatives: Compared with Bisphenol A, the Majority of Alternatives Are More Cytotoxic and Dysregulate More Genes in Avian Hepatocytes","year":2021,"lang":"en","type":"article","venue":"Environmental Toxicology and Chemistry","topic":"Effects and risks of endocrine disrupting chemicals","field":"Environmental Science","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa; Environment and Climate Change Canada","funders":"","keywords":"Bisphenol A; Environmental toxicology; Cytotoxic T cell; Chemistry; Cytotoxicity; Xenoestrogen; Toxicity; Biology; Pharmacology; Toxicology; In vitro; Environmental chemistry; Estrogen receptor; Genetics; Biochemistry; Organic chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002843783,0.0003533429,0.0002536962,0.0003031022,0.0002129091,0.0002656722,0.0001211646,0.0001942111,0.001252991],"category_scores_gemma":[0.0001842958,0.0001377224,0.0002821895,0.0003214166,0.0002203215,0.0001150117,0.0001641286,0.0001778447,0.0003016683],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00034922,"about_ca_system_score_gemma":0.0002143056,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004319644,"about_ca_topic_score_gemma":0.01065092,"domain_scores_codex":[0.9997041,0.0000697327,0.00003139372,0.00005493054,0.000114574,0.00002533997],"domain_scores_gemma":[0.9997405,0.00009144154,0.00003744992,0.00002815555,0.00008067572,0.00002175136],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001158264,0.00002673432,0.0008147091,0.0000351352,0.000007676945,0.0000275919,0.00001863951,0.0001817907,0.9979513,0.00001418926,0.00002651261,0.0007797483],"study_design_scores_gemma":[0.000006188423,0.0008914159,0.01172275,0.000003937331,0.00002965405,0.00009390009,0.00005613007,0.0005368669,0.9854077,0.00001235553,0.001233697,0.000005430528],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9924406,0.001035242,0.00305168,0.00004733298,0.00002632159,0.00009828717,0.001210892,0.00002571134,0.002064021],"genre_scores_gemma":[0.9797133,0.001611218,0.009666001,0.0001177905,0.00001074461,0.000134446,0.002733929,0.00002302783,0.005989515],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004319644,"threshold_uncertainty_score":0.00858897,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007578978098878773,"score_gpt":0.2731631635778399,"score_spread":0.2655841854789612,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}