{"id":"W3135292505","doi":"10.1093/jcag/gwab002.154","title":"A156 SERUM TUMOUR NECROSIS FACTOR-α ANTAGONIST DRUG CONCENTRATIONS IN PATIENTS WITH PYODERMA GANGRENOSUM ASSOSCIATED WITH INFLAMMATORY BOWEL DISEASE","year":2021,"lang":"en","type":"article","venue":"Journal of the Canadian Association of Gastroenterology","topic":"Autoimmune and Inflammatory Disorders","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"","keywords":"Infliximab; Adalimumab; Medicine; Inflammatory bowel disease; Dosing; Gastroenterology; Internal medicine; Tumor necrosis factor alpha; Therapeutic drug monitoring; Necrosis; Pyoderma gangrenosum; Disease; Pharmacokinetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002346356,0.0001466129,0.0003833767,0.0001862012,0.0001276616,0.00002834504,0.0001465118,0.00007750043,0.00007118331],"category_scores_gemma":[0.0002173714,0.0001069971,0.0001248223,0.0001793989,0.00008871426,0.0001837237,0.00001906045,0.0003846505,0.000001691872],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001123245,"about_ca_system_score_gemma":0.002055317,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006178169,"about_ca_topic_score_gemma":0.1957042,"domain_scores_codex":[0.9982166,0.00026006,0.0005956346,0.0001240021,0.0004322057,0.00037151],"domain_scores_gemma":[0.9975838,0.00003187001,0.001123833,0.0001836563,0.0007844207,0.0002924285],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0006591495,0.0001288885,0.9961482,0.00002242412,0.0002276411,0.00007402906,0.0002365456,0.0003227765,0.0001053835,0.0000102615,0.002052824,0.00001184786],"study_design_scores_gemma":[0.005617416,0.0003081294,0.9928725,0.0001653869,0.0001480261,0.00001274523,0.0001536047,0.00003731915,0.0001041093,0.00001006562,0.0005054692,0.00006523745],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9846174,0.00002075792,0.000004365865,0.01477735,0.0001963691,0.0001941991,0.0001165151,0.000004579136,0.00006851368],"genre_scores_gemma":[0.9978459,0.00001237397,0.00003163265,0.001699935,0.00003210989,0.000002469781,0.00003227268,0.00001859264,0.0003246959],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1950864,"threshold_uncertainty_score":0.8189721,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003392483311727742,"score_gpt":0.1871541000369593,"score_spread":0.1837616167252315,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}