{"id":"W3135292505","doi":"10.1093/jcag/gwab002.154","title":"A156 SERUM TUMOUR NECROSIS FACTOR-α ANTAGONIST DRUG CONCENTRATIONS IN PATIENTS WITH PYODERMA GANGRENOSUM ASSOSCIATED WITH INFLAMMATORY BOWEL DISEASE","year":2021,"lang":"en","type":"article","venue":"Journal of the Canadian Association of Gastroenterology","topic":"Autoimmune and Inflammatory Disorders","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"","keywords":"Infliximab; Adalimumab; Medicine; Inflammatory bowel disease; Dosing; Gastroenterology; Internal medicine; Tumor necrosis factor alpha; Therapeutic drug monitoring; Necrosis; Pyoderma gangrenosum; Disease; Pharmacokinetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002190603,0.0002488619,0.0004165425,0.0007619588,0.0003899853,0.0006204909,0.0001715737,0.0003434196,0.001518036],"category_scores_gemma":[0.001299436,0.0001347162,0.0002494018,0.0009489228,0.0002369728,0.0003921676,0.0002565941,0.0003843549,0.0001948272],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000286754,"about_ca_system_score_gemma":0.0002371392,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007440105,"about_ca_topic_score_gemma":0.000783733,"domain_scores_codex":[0.999637,0.00008230523,0.00007813056,0.00007722296,0.00006596511,0.00005920975],"domain_scores_gemma":[0.9991437,0.0002059182,0.0004306635,0.00001878739,0.00006479428,0.000136084],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0002524006,0.00003530478,0.9930427,0.00003330666,0.00002371623,0.002404633,0.00008634255,0.00004621407,0.0008258483,0.00001911703,0.00008845318,0.003141986],"study_design_scores_gemma":[0.00003139247,0.0004613596,0.9806152,0.00003413807,0.00005466248,0.01689296,0.0004543215,0.0003558329,0.0004565838,0.00005663086,0.0005780701,0.00000894392],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9978704,0.00109376,0.00007861701,0.00005801993,0.000006996634,0.000006243473,0.000062981,0.000005164788,0.0008178478],"genre_scores_gemma":[0.9995919,0.0001743844,0.00007628564,0.00003453274,0.00001214838,0.0000029591,0.00004810894,7.023427e-7,0.0000589659],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001518036,"threshold_uncertainty_score":0.005078375,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003392483311727742,"score_gpt":0.1871541000369593,"score_spread":0.1837616167252315,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}