{"id":"W3135306353","doi":"10.1093/jcag/gwab002.014","title":"A15 EFFICACY AND SAFETY OF FILGOTINIB AS INDUCTION THERAPY FOR PATIENTS WITH MODERATELY TO SEVERELY ACTIVE ULCERATIVE COLITIS: RESULTS FROM THE PHASE 2B/3 SELECTION STUDY","year":2021,"lang":"en","type":"article","venue":"Journal of the Canadian Association of Gastroenterology","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"","keywords":"Medicine; Internal medicine; Ulcerative colitis; Gastroenterology; Vedolizumab; Refractory (planetary science); Placebo; Adverse effect; Randomized controlled trial; Clinical endpoint; Surgery; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003914401,0.0007008383,0.001261606,0.0002937854,0.0003683511,0.0006919067,0.0004212889,0.0007583697,0.00468868],"category_scores_gemma":[0.001942416,0.0002866608,0.001234391,0.0003682353,0.0005425363,0.0004636304,0.0003010265,0.001569015,0.0006963169],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005768162,"about_ca_system_score_gemma":0.001286809,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007191405,"about_ca_topic_score_gemma":0.001671271,"domain_scores_codex":[0.9985568,0.0009869838,0.00008758259,0.0001083334,0.0001446827,0.0001156704],"domain_scores_gemma":[0.998742,0.0003221273,0.0004204343,0.0001032495,0.0001182608,0.0002939416],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.8365442,0.01760488,0.01517287,0.0007215632,0.001094236,0.000152316,0.0001618255,0.0005295399,0.01749502,0.0001211774,0.003896405,0.1065058],"study_design_scores_gemma":[0.6358485,0.3086687,0.04539228,0.00009833637,0.00122825,0.0002577082,0.00007072002,0.0007021697,0.003399176,0.0001841289,0.004117351,0.00003265198],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9889871,0.003824431,0.0004805202,0.0006651958,0.00005898599,0.002143161,0.001704159,0.00006349631,0.002072991],"genre_scores_gemma":[0.99008,0.001982218,0.001279298,0.001033399,0.0002113639,0.001414386,0.00268529,0.0000192421,0.001294712],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00468868,"threshold_uncertainty_score":0.02070159,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007884801886360898,"score_gpt":0.2442008545699434,"score_spread":0.2363160526835826,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}