{"id":"W3135320265","doi":"10.1093/jcag/gwab002.235","title":"A237 IMPROVEMENT IN ABDOMINAL SYMPTOMS WITH LINACLOTIDE IN PATIENTS WITH IRRITABLE BOWEL SYNDROME WITH CONSTIPATION: RESULTS FROM A PHASE 3B TRIAL","year":2021,"lang":"en","type":"article","venue":"Journal of the Canadian Association of Gastroenterology","topic":"Gastrointestinal motility and disorders","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"ABB (Canada); Université de Montréal","funders":"","keywords":"Medicine; Bloating; Abdominal pain; Irritable bowel syndrome; Clinical endpoint; Constipation; Internal medicine; Placebo; Gastroenterology; Defecation; Intention-to-treat analysis; Randomized controlled trial","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001511965,0.001076151,0.002347952,0.000278585,0.0003433533,0.001004411,0.000616571,0.001266096,0.005357883],"category_scores_gemma":[0.0008044055,0.0003157724,0.002177417,0.0003390738,0.0005562993,0.0005403805,0.0002348913,0.002109666,0.00107934],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004300681,"about_ca_system_score_gemma":0.0008611816,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007925527,"about_ca_topic_score_gemma":0.001762803,"domain_scores_codex":[0.9995666,0.0002374619,0.00002901639,0.00005698324,0.00004642922,0.00006337298],"domain_scores_gemma":[0.9993466,0.0001600439,0.0001182196,0.0000359505,0.00006311297,0.0002761119],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8734732,0.01580885,0.002583146,0.003106532,0.004969003,0.0002656323,0.00009350618,0.0007107024,0.01851005,0.0001508914,0.005241466,0.0750869],"study_design_scores_gemma":[0.8470657,0.1403749,0.00780525,0.0001431398,0.0011201,0.0001703465,0.00004081487,0.0004476932,0.000858054,0.0001441927,0.001796597,0.00003311524],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9627728,0.02793667,0.0005620698,0.001248989,0.0004496826,0.001936069,0.002055862,0.000231249,0.002806567],"genre_scores_gemma":[0.9772034,0.01104323,0.001348276,0.002688698,0.0005105222,0.002395317,0.002584507,0.00004417,0.002182012],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005357883,"threshold_uncertainty_score":0.01792395,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005497442664052367,"score_gpt":0.2109877827152998,"score_spread":0.2054903400512475,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}