{"id":"W3135320568","doi":"10.21037/tlcr-21-145","title":"Triptolide inhibits epithelial-mesenchymal transition phenotype through the p70S6k/GSK3/β-catenin signaling pathway in taxol-resistant human lung adenocarcinoma","year":2021,"lang":"en","type":"article","venue":"Translational Lung Cancer Research","topic":"Natural Compounds in Disease Treatment","field":"Medicine","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network; Toronto General Hospital; University of Toronto","funders":"Natural Science Foundation of Shandong Province; National Science Foundation","keywords":"Triptolide; Cancer research; Cell cycle; Apoptosis; Epithelial–mesenchymal transition; Cell growth; TUNEL assay; Viability assay; A549 cell; Lung cancer; Medicine; Biology; Cancer; Pathology; Internal medicine; Metastasis; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006219439,0.0001998328,0.000247381,0.0002678832,0.0001151016,0.0001198629,0.000125624,0.000141372,0.0009174381],"category_scores_gemma":[0.00005969583,0.00006875153,0.0002184198,0.0001662779,0.0001052805,0.000112999,0.00008156582,0.0003571565,0.0001965125],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001390013,"about_ca_system_score_gemma":0.0001702579,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004617179,"about_ca_topic_score_gemma":0.0007600587,"domain_scores_codex":[0.9999664,0.0000051536,0.000005035658,0.00000503537,0.000009383815,0.000009040349],"domain_scores_gemma":[0.9999708,0.000005445471,0.000007446946,0.000002761789,0.00000463022,0.000008988738],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006123525,0.0001668889,0.0004806316,0.0001598424,0.00001806572,0.0001342282,0.00002139842,0.0001529868,0.9934309,0.00004506583,0.0001737448,0.004603905],"study_design_scores_gemma":[0.0002698346,0.003508494,0.01051487,0.00001836936,0.0001010161,0.0008092748,0.00006566924,0.001898045,0.9790066,0.00007151752,0.003726957,0.000009339415],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9955744,0.002475838,0.0005925397,0.00008988192,0.00002690542,0.00004188956,0.0002733536,0.00004547216,0.0008796836],"genre_scores_gemma":[0.9949228,0.002311655,0.0008472688,0.00006536913,0.00001435275,0.0000597082,0.0005873177,0.000007759776,0.001183619],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009174381,"threshold_uncertainty_score":0.003069103,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07082833757933409,"score_gpt":0.4004624317800755,"score_spread":0.3296340942007414,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}