{"id":"W3135320785","doi":"10.1053/j.gastro.2021.02.061","title":"X Chromosome Contribution to the Genetic Architecture of Primary Biliary Cholangitis","year":2021,"lang":"en","type":"article","venue":"Gastroenterology","topic":"Liver Diseases and Immunity","field":"Medicine","cited_by":52,"is_retracted":false,"has_abstract":false,"ca_institutions":"Mount Sinai Hospital; Lunenfeld-Tanenbaum Research Institute; Toronto General Hospital; University of Toronto","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Natural Science Foundation of China-Yunnan Joint Fund; Japan Society for the Promotion of Science; Medical Research Council; American Medical Association Foundation; National Institutes of Health; Ministero della Salute; Academy of Medical Sciences; National Institute for Health and Care Research; National Natural Science Foundation of China; Japan Agency for Medical Research and Development","keywords":"Genetic architecture; Chromosome; Primary sclerosing cholangitis; Gastroenterology; Biology; Genetics; Internal medicine; Medicine; Gene; Disease; Phenotype","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006178609,0.00007449292,0.0002130668,0.00003616788,0.00003610691,0.000004090157,0.00008477834,0.00003681586,0.0001890277],"category_scores_gemma":[0.0000666393,0.00005203852,0.00009646293,0.00008565185,0.00006335856,0.00001338721,0.0001108868,0.0001411391,0.0000202195],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003430219,"about_ca_system_score_gemma":0.00005694247,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002021279,"about_ca_topic_score_gemma":0.00001790601,"domain_scores_codex":[0.9992689,0.0001277772,0.0001548466,0.0001405239,0.0001005814,0.0002073117],"domain_scores_gemma":[0.9993879,0.0000242579,0.00004020717,0.0003449339,0.0001140479,0.00008864859],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001320962,0.0004298809,0.9001938,0.0001137635,0.0002640693,0.0002011567,0.0002370157,0.00007296047,0.08815595,0.00003587517,0.003381327,0.005593264],"study_design_scores_gemma":[0.001075276,0.0007735799,0.9920573,0.00002989116,0.0001036117,0.0004753296,0.000022396,0.00000787105,0.001579657,0.00004112633,0.003809243,0.00002477563],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9914473,0.0005230277,0.001323475,0.006160715,0.000147907,0.0002081176,0.00008166975,0.00001409093,0.00009369894],"genre_scores_gemma":[0.9932479,0.00005261797,0.000470622,0.005871507,0.0001301007,0.00001461189,0.0001299701,0.00000730289,0.00007538265],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09186347,"threshold_uncertainty_score":0.2122069,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007477492342311376,"score_gpt":0.2237765642564558,"score_spread":0.2162990719141444,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}