{"id":"W3135320785","doi":"10.1053/j.gastro.2021.02.061","title":"X Chromosome Contribution to the Genetic Architecture of Primary Biliary Cholangitis","year":2021,"lang":"en","type":"article","venue":"Gastroenterology","topic":"Liver Diseases and Immunity","field":"Medicine","cited_by":52,"is_retracted":false,"has_abstract":false,"ca_institutions":"Mount Sinai Hospital; Lunenfeld-Tanenbaum Research Institute; Toronto General Hospital; University of Toronto","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Natural Science Foundation of China-Yunnan Joint Fund; Japan Society for the Promotion of Science; Medical Research Council; American Medical Association Foundation; National Institutes of Health; Ministero della Salute; Academy of Medical Sciences; National Institute for Health and Care Research; National Natural Science Foundation of China; Japan Agency for Medical Research and Development","keywords":"Genetic architecture; Chromosome; Primary sclerosing cholangitis; Gastroenterology; Biology; Genetics; Internal medicine; Medicine; Gene; Disease; Phenotype","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002301297,0.0004614941,0.0003602877,0.001479534,0.0004283268,0.0005111217,0.0003556991,0.0004285756,0.0043951],"category_scores_gemma":[0.0009912216,0.0003006685,0.0002766726,0.0007836485,0.0006437323,0.0002247011,0.0004863583,0.0003657985,0.0002786203],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002186753,"about_ca_system_score_gemma":0.0002266845,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001138228,"about_ca_topic_score_gemma":0.0008200465,"domain_scores_codex":[0.9995882,0.0001516773,0.00003158645,0.0000720336,0.0000812526,0.00007525581],"domain_scores_gemma":[0.9993126,0.0003204388,0.0001813522,0.00006301689,0.00004417951,0.0000784465],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.004284221,0.0002377571,0.7622359,0.0002603735,0.0006066578,0.02946686,0.0009266664,0.00221532,0.1560261,0.006765592,0.0007051344,0.03626943],"study_design_scores_gemma":[0.00009265444,0.0003013356,0.9496737,0.00006458756,0.000382671,0.02898018,0.0004477706,0.001351043,0.01411539,0.002754891,0.001810222,0.000025629],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9961933,0.001032644,0.0003759004,0.0001974696,0.0000136652,0.000007483856,0.00007924586,0.00001769209,0.00208266],"genre_scores_gemma":[0.9988195,0.0004501604,0.0001786401,0.0000178876,0.00003014909,0.000002348577,0.00004282084,0.000007531316,0.0004508543],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0043951,"threshold_uncertainty_score":0.01470309,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007477492342311376,"score_gpt":0.2237765642564558,"score_spread":0.2162990719141444,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}