{"id":"W3135327518","doi":"10.1126/scitranslmed.abe1433","title":"Prosaposin mediates inflammation in atherosclerosis","year":2021,"lang":"en","type":"article","venue":"Science Translational Medicine","topic":"Lysosomal Storage Disorders Research","field":"Medicine","cited_by":101,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"H2020 European Research Council; National Institute on Drug Abuse; National Heart, Lung, and Blood Institute; Horizon 2020; Courant Forschungszentrum Geobiologie, Georg-August-Universität Göttingen; National Institute of Biomedical Imaging and Bioengineering; European Research Council; National Institutes of Health; Agence Nationale de la Recherche; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; American Heart Association; Emissions Reduction Alberta; Hartstichting; Teikyo University School of Medicine; ZonMw; National Heart Foundation of Australia; Horizon 2020 Framework Programme; Deutsche Forschungsgemeinschaft","keywords":"Inflammation; PI3K/AKT/mTOR pathway; Apolipoprotein E; P70-S6 Kinase 1; Biology; Cell biology; Signal transduction; Cancer research; Regulator; Immunology; Medicine; Gene; Internal medicine; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002868259,0.0004375114,0.0002257663,0.0003716006,0.0002802569,0.0004685147,0.0001138578,0.0003351884,0.001757977],"category_scores_gemma":[0.0002443707,0.0001306946,0.0001902357,0.0001979364,0.0002400288,0.0003130131,0.0004041367,0.0004781922,0.0003307715],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001958757,"about_ca_system_score_gemma":0.0001593945,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001963494,"about_ca_topic_score_gemma":0.0002442349,"domain_scores_codex":[0.9998492,0.00005141728,0.000009293944,0.00003064708,0.00002908095,0.00003029303],"domain_scores_gemma":[0.9998987,0.00001489255,0.00002933862,0.000008437396,0.00001409519,0.00003465269],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002295939,0.00008991929,0.003959375,0.0001940957,0.00003698641,0.0008936762,0.0001650053,0.0001773995,0.9836752,0.0005293864,0.000396973,0.007586203],"study_design_scores_gemma":[0.0003091693,0.002075335,0.2713927,0.0001924908,0.0002133568,0.006090465,0.001073568,0.004852904,0.6934693,0.002957383,0.01730424,0.00006898051],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9884788,0.007437994,0.001084254,0.0003678899,0.00005356469,0.00002819658,0.000282645,0.00002539798,0.00224107],"genre_scores_gemma":[0.9946973,0.002492683,0.0004717654,0.00009961657,0.00006085845,0.00004427694,0.0002603624,0.000005277255,0.001867833],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001757977,"threshold_uncertainty_score":0.005881011,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04259678786237805,"score_gpt":0.3414013470639785,"score_spread":0.2988045592016004,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}