{"id":"W3135330127","doi":"10.1101/2021.03.07.21252647","title":"Transmission, infectivity, and antibody neutralization of an emerging SARS-CoV-2 variant in California carrying a L452R spike protein mutation","year":2021,"lang":"en","type":"preprint","venue":"medRxiv","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":247,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Canadian Institutes of Health Research; Innovative Genomics Institute; University of California, San Francisco; California Department of Public Health; Roddenberry Foundation; National Institutes of Health","keywords":"Neutralization; Infectivity; Virology; Antibody; Titer; Neutralizing antibody; Biology; Spike Protein; Mutation; Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); Transmission (telecommunications); Virus; Coronavirus disease 2019 (COVID-19); Gene; Immunology; Medicine; Genetics; Infectious disease (medical specialty); Disease","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001121148,0.0003226127,0.0006923773,0.0006440788,0.00007206474,0.00007983189,0.0001552708,0.0003803702,0.000007286289],"category_scores_gemma":[0.0003143534,0.000314726,0.000126443,0.0006359086,0.00009296196,0.0001724213,0.0001951937,0.0007714383,0.00000183084],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001144405,"about_ca_system_score_gemma":0.0006491436,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003517642,"about_ca_topic_score_gemma":0.0006064161,"domain_scores_codex":[0.9972342,0.0003993215,0.0006565265,0.0007515058,0.0005887819,0.0003696322],"domain_scores_gemma":[0.9988819,0.00006046679,0.0002196804,0.0004950988,0.0002858169,0.00005702533],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001569285,0.0003282262,0.1213318,0.002576816,0.0000550845,0.0008148272,0.002001456,0.00004679528,0.8658925,0.00003006193,0.000001112855,0.006764383],"study_design_scores_gemma":[0.001717155,0.0002153933,0.0672565,0.002405306,0.0001079876,0.0001426087,0.000178051,0.01990099,0.9066944,0.0004799333,0.0005579707,0.0003436906],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9824749,0.0004520365,0.0151585,0.00023286,0.00009455292,0.001347262,0.00001608408,0.00006368284,0.0001601044],"genre_scores_gemma":[0.998103,0.00002807345,0.0007954618,0.0007034224,0.00008384317,0.0001186272,0.000105575,0.00005999949,0.000001949522],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05407532,"threshold_uncertainty_score":0.9999305,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04302612145559004,"score_gpt":0.3735173772957778,"score_spread":0.3304912558401878,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}