{"id":"W3135330127","doi":"10.1101/2021.03.07.21252647","title":"Transmission, infectivity, and antibody neutralization of an emerging SARS-CoV-2 variant in California carrying a L452R spike protein mutation","year":2021,"lang":"en","type":"preprint","venue":"medRxiv","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":247,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Canadian Institutes of Health Research; Innovative Genomics Institute; University of California, San Francisco; California Department of Public Health; Roddenberry Foundation; National Institutes of Health","keywords":"Neutralization; Infectivity; Virology; Antibody; Titer; Neutralizing antibody; Biology; Spike Protein; Mutation; Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); Transmission (telecommunications); Virus; Coronavirus disease 2019 (COVID-19); Gene; Immunology; Medicine; Genetics; Infectious disease (medical specialty); Disease","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001583382,0.000189017,0.0001014721,0.0001865894,0.0003038957,0.00030027,0.0001334179,0.0001303532,0.0004617832],"category_scores_gemma":[0.0001583461,0.000131142,0.000133345,0.0001424977,0.0001255976,0.00009094755,0.0001145951,0.0002598483,0.0001095082],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005348496,"about_ca_system_score_gemma":0.000296533,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.05165975,"about_ca_topic_score_gemma":0.0444615,"domain_scores_codex":[0.9999,0.0000105138,0.00000522977,0.00003525992,0.00002503844,0.00002393609],"domain_scores_gemma":[0.9999145,0.00001225908,0.00002491753,0.000006862038,0.0000169351,0.00002450559],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001681521,0.0006432662,0.5894587,0.00008627465,0.000126135,0.001876289,0.001146555,0.001407632,0.3887073,0.0002852569,0.001654396,0.01292657],"study_design_scores_gemma":[0.00005563987,0.0007163748,0.9826873,0.00001137507,0.00004416882,0.001114015,0.0003677097,0.00159948,0.01199909,0.00003420989,0.001359072,0.00001148561],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9994552,0.000052539,0.00003204999,0.000008132663,0.000001877697,0.000003232362,0.0001246023,0.000002218906,0.0003201854],"genre_scores_gemma":[0.9988212,0.00008366492,0.0001783291,0.00001231897,0.000002750539,0.000002590411,0.0005077818,0.000001881211,0.0003894825],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05165975,"threshold_uncertainty_score":0.1027181,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04302612145559004,"score_gpt":0.3735173772957778,"score_spread":0.3304912558401878,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}