{"id":"W3135330625","doi":"10.1111/febs.15809","title":"Immunogenicity and humanization of single‐domain antibodies","year":2021,"lang":"en","type":"review","venue":"FEBS Journal","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":176,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa; National Research Council Canada","funders":"National Research Council Canada","keywords":"Immunogenicity; Single-domain antibody; Epitope; Computational biology; Antibody; Heavy chain; Biology; Immunology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001093934,0.0002432969,0.000255703,0.0002483849,0.00005769796,0.000461281,0.0002111647,0.0003657592,0.000868823],"category_scores_gemma":[0.0008661551,0.00008725061,0.0003462698,0.0001683472,0.0002464588,0.0004135748,0.0001983886,0.000464362,0.0002709978],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002318904,"about_ca_system_score_gemma":0.0001798055,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001532134,"about_ca_topic_score_gemma":0.00009676229,"domain_scores_codex":[0.9994656,0.0002001286,0.00005505462,0.00007526352,0.0001412963,0.00006259215],"domain_scores_gemma":[0.9995358,0.0002126326,0.0001369761,0.00002788047,0.0000647964,0.00002184327],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0009646122,0.0002387257,0.004095493,0.009716433,0.0002750802,0.0006261767,0.0002283598,0.001284188,0.2591492,0.006758948,0.004395272,0.7122675],"study_design_scores_gemma":[0.0001474035,0.009383492,0.01828602,0.00205691,0.000755062,0.01040031,0.0001875341,0.001098865,0.4489503,0.003701025,0.5049893,0.00004379104],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.1950483,0.7714512,0.01444075,0.001906188,0.0004487558,0.0001437875,0.0002611075,0.0001032923,0.01619663],"genre_scores_gemma":[0.5954739,0.3907945,0.006229684,0.001974807,0.000721322,0.0001299009,0.0004428316,0.00003124316,0.004201814],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.001093934,"threshold_uncertainty_score":0.005785346,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09549072456749548,"score_gpt":0.3885351676027212,"score_spread":0.2930444430352257,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}