{"id":"W3135330625","doi":"10.1111/febs.15809","title":"Immunogenicity and humanization of single‐domain antibodies","year":2021,"lang":"en","type":"review","venue":"FEBS Journal","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":176,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa; National Research Council Canada","funders":"National Research Council Canada","keywords":"Immunogenicity; Single-domain antibody; Epitope; Computational biology; Antibody; Heavy chain; Biology; Immunology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000413992,0.0002575092,0.001641135,0.0002522336,0.0001730208,0.00006434157,0.0001275915,0.0001960938,0.0004318897],"category_scores_gemma":[0.0001598363,0.0001787433,0.0005020123,0.0002484561,0.0001723049,0.00006116724,0.0001529131,0.0007016491,0.0000123309],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000787029,"about_ca_system_score_gemma":0.0004090923,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000112963,"about_ca_topic_score_gemma":0.000002573518,"domain_scores_codex":[0.9981105,0.0002201274,0.0007220133,0.0002049316,0.0004811271,0.0002613368],"domain_scores_gemma":[0.9987724,0.0001341893,0.0004047903,0.0001792519,0.0003436559,0.0001656929],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00006224276,0.0002460025,0.0004341709,0.01927888,0.001183676,0.0006208338,0.0001866084,9.44246e-8,0.0003681816,0.0006298085,0.002144008,0.9748455],"study_design_scores_gemma":[0.0003005738,0.0002618323,0.000221482,0.0190422,0.0005970763,0.00848959,0.00005252495,6.656942e-7,0.000046612,0.0001090084,0.9707138,0.0001646551],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.002056976,0.9957978,0.00004181275,0.00008987273,0.0001754946,0.0002029486,0.00003349589,0.000007246356,0.001594333],"genre_scores_gemma":[0.00007193469,0.9964369,0.0009251711,0.00002626867,0.0005570179,0.000002096153,0.0001044131,0.00003332229,0.001842876],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9746808,"threshold_uncertainty_score":0.7288942,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09549072456749548,"score_gpt":0.3885351676027212,"score_spread":0.2930444430352257,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}