{"id":"W3135375269","doi":"10.1371/journal.pgen.1009398","title":"MOSTWAS: Multi-Omic Strategies for Transcriptome-Wide Association Studies","year":2021,"lang":"en","type":"article","venue":"PLoS Genetics","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":82,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Institute of Child Health and Human Development; National Cancer Institute; National Institute of Mental Health; National Heart, Lung, and Blood Institute; Medical Research Council; National Institute of Environmental Health Sciences; Hjartavernd; Gillings School of Public Health; National Institutes of Health; Canadian Institutes of Health Research; National Institute of General Medical Sciences; Centre hospitalier régional universitaire de Lille; Erasmus Medisch Centrum; Bundesministerium für Bildung und Forschung; Institut National de la Santé et de la Recherche Médicale; Cancer Research UK; Wellcome Trust; Agence Nationale de la Recherche; U.S. Department of Defense; European Commission; New York Genome Center; Lieber Institute for Brain Development; University of California, San Francisco; Development of Innovative Strategies for a Transdisciplinary approach to ALZheimer's disease; Yale University; University of Chicago; National Institute on Aging; Alzheimer's Association","keywords":"Biology; Transcriptome; Computational biology; Omics; Genome-wide association study; Association (psychology); Bioinformatics; Evolutionary biology; Genetics; Gene; Single-nucleotide polymorphism; Gene expression; Genotype","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002753908,0.0001830668,0.0002949996,0.0000287997,0.0001425339,0.00003466461,0.0001351147,0.0002683196,0.0000121488],"category_scores_gemma":[0.00182083,0.0001917161,0.0001599581,0.00008796543,0.00004066234,0.000003374874,0.00006023718,0.00008082663,0.00001141619],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007112615,"about_ca_system_score_gemma":0.000229489,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000001600863,"about_ca_topic_score_gemma":0.0001318945,"domain_scores_codex":[0.9986023,0.0001358403,0.00035596,0.0003962905,0.0001237731,0.0003857923],"domain_scores_gemma":[0.9986553,0.0002544018,0.0001656404,0.0002860585,0.0005742377,0.00006432777],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004162622,0.0003877475,0.1782496,0.0001489576,0.001702997,0.000003226036,0.0007746672,0.00268945,0.751529,0.0001283048,0.06352033,0.0008240955],"study_design_scores_gemma":[0.004892855,0.000943815,0.04041872,0.00006207139,0.0008206279,0.000009429381,0.01015774,0.006890945,0.7238868,0.005390194,0.2051434,0.001383321],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9760314,0.01100698,0.009405358,0.002449887,0.0004282063,0.0003166946,0.0001162319,0.00002477117,0.0002204483],"genre_scores_gemma":[0.9716278,0.003685184,0.01814993,0.002776545,0.0003735657,0.0001596543,0.0003590966,0.00004523943,0.002822965],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1416231,"threshold_uncertainty_score":0.7817955,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0553038562684704,"score_gpt":0.3192351587865901,"score_spread":0.2639313025181197,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}