{"id":"W3135375269","doi":"10.1371/journal.pgen.1009398","title":"MOSTWAS: Multi-Omic Strategies for Transcriptome-Wide Association Studies","year":2021,"lang":"en","type":"article","venue":"PLoS Genetics","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":82,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Institute of Child Health and Human Development; National Cancer Institute; National Institute of Mental Health; National Heart, Lung, and Blood Institute; Medical Research Council; National Institute of Environmental Health Sciences; Hjartavernd; Gillings School of Public Health; National Institutes of Health; Canadian Institutes of Health Research; National Institute of General Medical Sciences; Centre hospitalier régional universitaire de Lille; Erasmus Medisch Centrum; Bundesministerium für Bildung und Forschung; Institut National de la Santé et de la Recherche Médicale; Cancer Research UK; Wellcome Trust; Agence Nationale de la Recherche; U.S. Department of Defense; European Commission; New York Genome Center; Lieber Institute for Brain Development; University of California, San Francisco; Development of Innovative Strategies for a Transdisciplinary approach to ALZheimer's disease; Yale University; University of Chicago; National Institute on Aging; Alzheimer's Association","keywords":"Biology; Transcriptome; Computational biology; Omics; Genome-wide association study; Association (psychology); Bioinformatics; Evolutionary biology; Genetics; Gene; Single-nucleotide polymorphism; Gene expression; Genotype","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.02514347,0.003162246,0.003003553,0.004378805,0.001574285,0.004334304,0.004964972,0.002383232,0.0114857],"category_scores_gemma":[0.04287674,0.002164662,0.006356862,0.005198351,0.001617037,0.002567312,0.006700149,0.005150003,0.003776145],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009615513,"about_ca_system_score_gemma":0.002804047,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002284061,"about_ca_topic_score_gemma":0.003501293,"domain_scores_codex":[0.9919207,0.005673091,0.0003797803,0.001089587,0.0007513521,0.000185464],"domain_scores_gemma":[0.9800053,0.01440903,0.0008671081,0.003614482,0.0007128862,0.0003912345],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.001362305,0.0003669956,0.02103396,0.003319182,0.01020285,0.00221194,0.001255388,0.2012381,0.01760786,0.1914462,0.05033454,0.4996206],"study_design_scores_gemma":[0.0003084593,0.0001789341,0.003428973,0.0003049569,0.001040958,0.0005471596,0.000144538,0.4783153,0.005037343,0.4727856,0.03775553,0.0001522305],"study_design_candidate":"simulation_or_modeling","study_design_consensus":null,"genre_codex":"methods","genre_gemma":"methods","genre_scores_codex":[0.0009900008,0.000421195,0.992641,0.0003801141,0.00008684397,0.00008032779,0.001535904,0.003388056,0.0004765158],"genre_scores_gemma":[0.03843677,0.0007885557,0.9514438,0.0007774971,0.000215695,0.001217621,0.004073085,0.002091705,0.0009552116],"genre_candidate":"methods","genre_consensus":"methods","teacher_disagreement_score":0.02514347,"threshold_uncertainty_score":0.132973,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0553038562684704,"score_gpt":0.3192351587865901,"score_spread":0.2639313025181197,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}