{"id":"W3135409505","doi":"10.1128/aac.02346-20","title":"Development and Validation of an <i>In Silico</i> Decision Tool To Guide Optimization of Intravenous Artesunate Dosing Regimens for Severe Falciparum Malaria Patients","year":2021,"lang":"en","type":"article","venue":"Antimicrobial Agents and Chemotherapy","topic":"Malaria Research and Control","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"Australian Research Council; Wellcome Trust; Department of Health and Aged Care, Australian Government; Wellcome; Mahidol University; National Health and Medical Research Council; Bill and Melinda Gates Foundation","keywords":"Artesunate; Malaria; Dosing; Plasmodium falciparum; Medicine; Intensive care medicine; Pharmacology; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003835592,0.00105244,0.001031324,0.0009264118,0.0004284812,0.001858595,0.001036724,0.00121898,0.003231873],"category_scores_gemma":[0.01153816,0.0005881568,0.0009898886,0.000374925,0.0003687021,0.0006408753,0.0007021193,0.0009119944,0.0006988718],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008700747,"about_ca_system_score_gemma":0.002839037,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.006451513,"about_ca_topic_score_gemma":0.004996886,"domain_scores_codex":[0.998876,0.0006706138,0.00008157689,0.0001383074,0.0001509907,0.00008243127],"domain_scores_gemma":[0.9925769,0.005533639,0.0005213107,0.0002010569,0.000970682,0.0001962629],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.0003785424,0.0002156164,0.008445561,0.0001075966,0.0001395431,0.0001495765,0.00005542824,0.94278,0.001874959,0.002172891,0.003102191,0.04057816],"study_design_scores_gemma":[0.00002766788,0.00003271886,0.0001681664,0.000009350924,0.00001041763,0.00001385849,0.000007033893,0.9982172,0.0006753518,0.000463037,0.0003705644,0.000004563661],"study_design_candidate":"simulation_or_modeling","study_design_consensus":"simulation_or_modeling","genre_codex":"methods","genre_gemma":"methods","genre_scores_codex":[0.1853649,0.0002813613,0.7925664,0.00123844,0.0001315491,0.0005170676,0.001618159,0.008871206,0.009410935],"genre_scores_gemma":[0.7540957,0.000108441,0.2416375,0.0005238316,0.00004170329,0.0003439567,0.001753445,0.0002447542,0.001250747],"genre_candidate":"methods","genre_consensus":"methods","teacher_disagreement_score":0.006451513,"threshold_uncertainty_score":0.02028477,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01264789116924355,"score_gpt":0.274614648166719,"score_spread":0.2619667569974755,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}