{"id":"W3135423629","doi":"10.1038/s41523-021-00226-8","title":"Effects of obesity on breast aromatase expression and systemic metabo-inflammation in women with BRCA1 or BRCA2 mutations","year":2021,"lang":"en","type":"article","venue":"npj Breast Cancer","topic":"Cancer Risks and Factors","field":"Medicine","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Botwinick-Wolfensohn Foundation; Memorial Sloan-Kettering Cancer Center; Breast Cancer Research Foundation; National Cancer Institute; National Institutes of Health; Conquer Cancer Foundation; U.S. Department of Health and Human Services","keywords":"Breast cancer; Aromatase; Medicine; Internal medicine; Endocrinology; Leptin; Body mass index; Adiponectin; Adipose tissue; Obesity; Cancer; Oncology; Insulin resistance","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008940234,0.0001497958,0.0003824213,0.0001049184,0.00004050872,0.0000151289,0.00003557643,0.00006896542,0.0002052967],"category_scores_gemma":[0.0000195759,0.0001035794,0.00002652393,0.0002712283,0.00004326781,0.000119706,0.00002295447,0.000129874,0.000003180852],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003712708,"about_ca_system_score_gemma":0.000320818,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009060082,"about_ca_topic_score_gemma":0.0005470854,"domain_scores_codex":[0.9989868,0.00005809738,0.0002304609,0.0002755172,0.0002558252,0.000193307],"domain_scores_gemma":[0.9993463,0.00007889171,0.0001253749,0.0002061438,0.0001118176,0.0001314392],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.01186479,0.0008151773,0.3669624,0.005457407,0.0003385369,0.0006494267,0.005230187,0.000411579,0.4549516,0.00005793939,0.0003688016,0.1528922],"study_design_scores_gemma":[0.004051501,0.0001180461,0.9548486,0.002900534,0.0001096593,0.0008418284,0.0004402757,0.00005847758,0.03637876,0.00001133363,0.0001053858,0.0001355498],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9982003,0.0006280834,0.00003905004,0.0003251005,0.00007986537,0.0004038909,0.0002437749,0.00002798872,0.00005194339],"genre_scores_gemma":[0.9991342,0.0002435518,0.0000616594,0.00007762258,0.0001081853,0.0001755419,0.00003220751,0.00001974825,0.0001473146],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5878863,"threshold_uncertainty_score":0.4223845,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006200436157666598,"score_gpt":0.250666901086488,"score_spread":0.2444664649288214,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}