{"id":"W3135432136","doi":"","title":"Enhanced liposomal retention of irinotecan is correlated to increases in plasma irinotecan AUC and improved efficacy against a model of colorectal cancer","year":2005,"lang":"en","type":"article","venue":"Cancer Research","topic":"Nanoparticle-Based Drug Delivery","field":"Materials Science","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency","funders":"","keywords":"Irinotecan; Liposome; Chemistry; Pharmacology; Colorectal cancer; Cancer; Biochemistry; Internal medicine; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001943013,0.0005180207,0.0006072142,0.0004122061,0.000146515,0.0003478502,0.0002821796,0.0003330132,0.001211255],"category_scores_gemma":[0.0001089741,0.0001762729,0.0002383207,0.0002365674,0.000343095,0.0003003373,0.0001657144,0.0009663924,0.0003959989],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007736112,"about_ca_system_score_gemma":0.0003770198,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00104274,"about_ca_topic_score_gemma":0.001277783,"domain_scores_codex":[0.9998299,0.00002306472,0.0000124278,0.0000370561,0.00004639744,0.00005115297],"domain_scores_gemma":[0.9998657,0.00001398164,0.00004843058,0.00001589585,0.00001745308,0.00003866644],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004926919,0.0001397959,0.00007159275,0.00002690862,0.000005293223,0.00002157624,0.000008076869,0.00006601437,0.9982382,0.00002190888,0.00002907352,0.0008789037],"study_design_scores_gemma":[0.00004005162,0.001598059,0.00097297,0.000002255162,0.00001456646,0.00007886787,0.000008314141,0.0005955601,0.9962991,0.000008447575,0.0003785495,0.000003380666],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9965989,0.0008438212,0.00155109,0.0001081863,0.00002721044,0.00005354265,0.0001857054,0.0001166693,0.0005149206],"genre_scores_gemma":[0.9942502,0.000634388,0.002164723,0.00003861905,0.00001270663,0.0000606992,0.0003308751,0.00002233054,0.002485477],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001211255,"threshold_uncertainty_score":0.005612969,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03939480418718636,"score_gpt":0.3324298527779297,"score_spread":0.2930350485907434,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}