{"id":"W3135433679","doi":"10.3324/haematol.2020.267914","title":"T-cell dysfunction in chronic lymphocytic leukemia from an epigenetic perspective","year":2021,"lang":"en","type":"review","venue":"Haematologica","topic":"Chronic Lymphocytic Leukemia Research","field":"Medicine","cited_by":40,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Cancer Research UK","keywords":"Epigenetics; Chronic lymphocytic leukemia; Epigenomics; Immunology; T cell; Epigenetic therapy; Immune system; Immune Dysfunction; Tumor microenvironment; Biology; Cell; Immunotherapy; Chimeric antigen receptor; Cancer research; Leukemia; Medicine; DNA methylation; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003343315,0.0005097203,0.0007224804,0.001477432,0.0001841981,0.0006355213,0.0004913395,0.0008159066,0.002238964],"category_scores_gemma":[0.0004142902,0.0001385319,0.0003407146,0.001160294,0.0004178733,0.0008505706,0.0004299314,0.00116203,0.0008324971],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004848384,"about_ca_system_score_gemma":0.0007888211,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009571835,"about_ca_topic_score_gemma":0.001536038,"domain_scores_codex":[0.999904,0.00002221437,0.00001455578,0.00001691057,0.00003048604,0.00001178516],"domain_scores_gemma":[0.999841,0.00008482674,0.00002134973,0.00000519485,0.00003501226,0.00001261548],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00007581487,0.00004713994,0.0003106143,0.01491083,0.0000739783,0.0002872636,0.00008187378,0.0003638187,0.003240599,0.005353175,0.02194961,0.9533053],"study_design_scores_gemma":[0.00001591738,0.000135748,0.001654007,0.003539385,0.0001201202,0.003259639,0.00008261185,0.0001111632,0.0009092137,0.00299806,0.9871574,0.00001676573],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.000125929,0.9986945,0.00008936295,0.0002880075,0.0001381861,0.000001894027,0.000009206155,0.00000473576,0.000648216],"genre_scores_gemma":[0.001066802,0.9980109,0.0001097825,0.0001826615,0.0001585631,0.000003514633,0.00001707239,8.132276e-7,0.0004498061],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002238964,"threshold_uncertainty_score":0.007490039,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06693291355595138,"score_gpt":0.3874413583571703,"score_spread":0.3205084448012189,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}