{"id":"W3135464920","doi":"10.3389/fgene.2021.642975","title":"Heart Enhancers: Development and Disease Control at a Distance","year":2021,"lang":"en","type":"review","venue":"Frontiers in Genetics","topic":"Congenital heart defects research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Hospital for Sick Children","funders":"Canadian Institutes of Health Research; Hospital for Sick Children; Ontario Ministry of Research and Innovation; Canada Research Chairs","keywords":"Enhancer; Biology; Computational biology; Genome; Transcription factor; Heart development; Effector; Gene; Disease; Genetics; Evolutionary biology; Cell biology; Medicine; Embryonic stem cell","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001706745,0.0003581968,0.0008634773,0.00008122061,0.00007978542,0.00004456301,0.0002135917,0.0002740326,0.0000133019],"category_scores_gemma":[0.0001348124,0.0003583146,0.0001915103,0.0001726793,0.0001355739,0.000001693562,0.0003684845,0.0002092566,0.000010664],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001867948,"about_ca_system_score_gemma":0.001034922,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":9.640543e-7,"about_ca_topic_score_gemma":0.00003821879,"domain_scores_codex":[0.9979643,0.0002053664,0.0004064829,0.0007329798,0.0002371775,0.0004537261],"domain_scores_gemma":[0.998951,0.00002416149,0.00007307649,0.0005338398,0.00005954486,0.0003584133],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00004921574,0.00005599994,0.0021389,0.004608902,0.0001994587,0.00007287774,0.00002589013,0.000003500411,0.00003190454,0.000002068346,0.01474302,0.9780682],"study_design_scores_gemma":[0.0003037888,0.00004181272,0.00008851724,0.001310556,0.00009686762,0.00001425268,0.000009721375,0.00002101982,0.0001035171,0.000005530587,0.9976233,0.000381076],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0007886335,0.9957063,0.00220359,0.00001799785,0.0003456542,0.0007597069,0.00009252863,0.000006006011,0.00007963792],"genre_scores_gemma":[0.0003288251,0.9917407,0.004853094,0.0000684302,0.000141384,0.0002307043,0.0003312085,0.00006424455,0.002241428],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9828803,"threshold_uncertainty_score":0.9998869,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01872198912547489,"score_gpt":0.3127893676424455,"score_spread":0.2940673785169706,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}