{"id":"W3135464920","doi":"10.3389/fgene.2021.642975","title":"Heart Enhancers: Development and Disease Control at a Distance","year":2021,"lang":"en","type":"review","venue":"Frontiers in Genetics","topic":"Congenital heart defects research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Hospital for Sick Children","funders":"Canadian Institutes of Health Research; Hospital for Sick Children; Ontario Ministry of Research and Innovation; Canada Research Chairs","keywords":"Enhancer; Biology; Computational biology; Genome; Transcription factor; Heart development; Effector; Gene; Disease; Genetics; Evolutionary biology; Cell biology; Medicine; Embryonic stem cell","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005675431,0.000811236,0.00123012,0.001433771,0.0002312759,0.001316557,0.0008797043,0.001212812,0.004610938],"category_scores_gemma":[0.0006324713,0.0002426151,0.0003556113,0.001244869,0.0006451722,0.001613001,0.0008718291,0.001809682,0.002755715],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006141479,"about_ca_system_score_gemma":0.001080587,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005321182,"about_ca_topic_score_gemma":0.0009798944,"domain_scores_codex":[0.9998463,0.00002662088,0.00002091818,0.00003376845,0.00005315873,0.00001910241],"domain_scores_gemma":[0.9997049,0.0001534849,0.00003540921,0.00001089839,0.00005738172,0.00003796239],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00009272624,0.00003017218,0.0001927471,0.009737619,0.00006791512,0.0002231322,0.00006841255,0.0004176646,0.003622651,0.01272693,0.03188968,0.9409303],"study_design_scores_gemma":[0.000007607686,0.00003204889,0.0003709676,0.001608857,0.00004207115,0.0007592596,0.00003292423,0.00003827792,0.000475138,0.002727705,0.993895,0.00001008312],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00009082513,0.998111,0.0002068759,0.0002970998,0.0002236047,0.000002074136,0.00002490665,0.00001190025,0.001031699],"genre_scores_gemma":[0.0007365659,0.9976341,0.0002007754,0.0002968794,0.0002012159,0.000004134793,0.00005389864,0.000003568782,0.000868854],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.004610938,"threshold_uncertainty_score":0.01542509,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01872198912547489,"score_gpt":0.3127893676424455,"score_spread":0.2940673785169706,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}