{"id":"W3135466700","doi":"10.1038/s41416-020-01253-1","title":"Transitions in oral and gut microbiome of HPV+ oropharyngeal squamous cell carcinoma following definitive chemoradiotherapy (ROMA LA-OPSCC study)","year":2021,"lang":"en","type":"article","venue":"British Journal of Cancer","topic":"Gut microbiota and health","field":"Biochemistry, Genetics and Molecular Biology","cited_by":47,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Sciences Centre; Sunnybrook Health Science Centre; University of Toronto; Toronto General Hospital; University Health Network; Princess Margaret Cancer Centre","funders":"Princess Margaret Cancer Foundation; American Society of Clinical Oncology","keywords":"Microbiome; Fusobacterium nucleatum; Internal medicine; Metagenomics; Saliva; Head and neck squamous-cell carcinoma; Stage (stratigraphy); Medicine; Gut flora; Cohort; Chemoradiotherapy; Oncology; Gastroenterology; Biology; Cancer; Head and neck cancer; Immunology; Bioinformatics; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001866944,0.0001040342,0.0003351409,0.00005799378,0.00004937883,0.00002917931,0.00008483497,0.00009478883,0.00006299361],"category_scores_gemma":[0.00001289242,0.0001252797,0.000127682,0.0001245655,0.00005454626,0.000009550093,0.00002168113,0.0001652566,1.729443e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003577109,"about_ca_system_score_gemma":0.0004020234,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004560207,"about_ca_topic_score_gemma":0.002528835,"domain_scores_codex":[0.9990644,0.0001277135,0.0003607669,0.0001768906,0.00008736781,0.000182888],"domain_scores_gemma":[0.9995525,0.00001159128,0.000139047,0.0000772803,0.000143202,0.00007632184],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0001250835,0.0004202939,0.0205144,0.00006952175,0.00005569329,0.001049103,0.0005455301,0.000007342956,0.9682104,0.000001625032,0.0003173524,0.008683637],"study_design_scores_gemma":[0.01216878,0.001286094,0.7232141,0.000162963,0.0001584228,0.003266649,0.0017422,0.000003559742,0.2537087,0.00002484695,0.003904416,0.000359267],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9691938,0.03013157,0.00002884989,0.0001176002,0.0001258245,0.0001041817,0.000089428,0.000001254541,0.00020751],"genre_scores_gemma":[0.9974128,0.00163879,0.0005532498,0.0001948135,0.00007935311,0.000003881829,0.00001416717,0.00001941374,0.0000835447],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7145017,"threshold_uncertainty_score":0.5108758,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008450015526898672,"score_gpt":0.2717968957179888,"score_spread":0.2633468801910901,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}