{"id":"W3135473217","doi":"10.1200/jco.2021.39.6_suppl.27","title":"Olaparib efficacy in patients with metastatic castration-resistant prostate cancer (mCRPC) carrying circulating tumor (ct) DNA alterations in <i>BRCA1</i>, <i>BRCA2</i> or <i>ATM</i>: Results from the PROfound study.","year":2021,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"PARP inhibition in cancer therapy","field":"Medicine","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"Juravinski Cancer Centre","funders":"","keywords":"Olaparib; Medicine; Enzalutamide; Oncology; Internal medicine; BRCA mutation; Cohort; Cancer; Proportional hazards model; Progression-free survival; Prostate cancer; Cancer research; Gene; Chemotherapy; Ovarian cancer; Poly ADP ribose polymerase; Androgen receptor; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004028497,0.0001870074,0.0003566371,0.0001653156,0.0000856971,0.0004608999,0.0001718723,0.0001480725,0.0007195697],"category_scores_gemma":[0.0006564929,0.0001023654,0.0003448711,0.0001926598,0.0001151646,0.0001807185,0.0001516796,0.000431213,0.0001311683],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003052913,"about_ca_system_score_gemma":0.0003127968,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004996951,"about_ca_topic_score_gemma":0.001554321,"domain_scores_codex":[0.9998354,0.00005730903,0.00001588951,0.00003523129,0.00003815988,0.000018116],"domain_scores_gemma":[0.9996672,0.00007703735,0.00009429439,0.00002646649,0.00002638285,0.0001086845],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.2304423,0.00521171,0.2969853,0.001393031,0.003230168,0.0008001729,0.0004187064,0.004644491,0.04379411,0.0002969615,0.005424854,0.4073582],"study_design_scores_gemma":[0.03520867,0.1421956,0.7938432,0.0002049748,0.002687313,0.003213994,0.0002684755,0.003176512,0.007203542,0.0005468018,0.01137598,0.00007501518],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9945425,0.003652426,0.0001266995,0.00007674256,0.00001384255,0.00006186689,0.0006233722,0.00001749458,0.0008849709],"genre_scores_gemma":[0.9985313,0.0005492857,0.0001142902,0.00007844007,0.00001681698,0.00001597182,0.0005275249,0.00000192004,0.0001643681],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007195697,"threshold_uncertainty_score":0.002407253,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1359905281967922,"score_gpt":0.4499388744119796,"score_spread":0.3139483462151874,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}