{"id":"W3135560340","doi":"10.1093/genetics/iyab033","title":"Reduced gene dosage of histone H4 prevents CENP-A mislocalization and chromosomal instability in <i>Saccharomyces cerevisiae</i>","year":2021,"lang":"en","type":"article","venue":"Genetics","topic":"Chromosomal and Genetic Variations","field":"Agricultural and Biological Sciences","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"National Cancer Institute; National Human Genome Research Institute; Canadian Institutes of Health Research; National Institutes of Health; Canadian Institute for Advanced Research","keywords":"SUMO protein; Saccharomyces cerevisiae; Biology; Ubiquitin ligase; Genome instability; Mutant; Histone; Gene; Ubiquitin; Genetics; Mutation; Cell biology; DNA damage; DNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001004499,0.0001085136,0.0001851642,0.000009312095,0.00006529492,0.00001954099,0.0001046908,0.0000897943,0.0002654701],"category_scores_gemma":[0.00004570376,0.00005795655,0.00004437743,0.0003524632,0.00005792483,0.00003599502,0.0001014888,0.00005606691,0.0000024454],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002433865,"about_ca_system_score_gemma":0.00002828901,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000471663,"about_ca_topic_score_gemma":0.0006589402,"domain_scores_codex":[0.9989671,0.00009876688,0.0003168607,0.0002927177,0.0001569367,0.0001676037],"domain_scores_gemma":[0.9996231,0.00005313324,0.0000895095,0.00008811732,0.00007703288,0.00006907943],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.000006670228,0.0001733218,0.03682246,0.00002553508,0.000007327228,0.000003894712,0.0001818459,0.00003930398,0.9463698,0.00005626648,0.00001772369,0.01629589],"study_design_scores_gemma":[0.0003408956,0.0001286322,0.560796,0.00004070472,0.0000225911,0.00002069747,0.0001356284,0.0004416684,0.4339779,0.0008071949,0.003102339,0.0001857934],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9970009,0.001968971,0.000007123603,0.0004752507,0.0000732757,0.0001578908,0.00008106051,0.0000126556,0.0002228906],"genre_scores_gemma":[0.9980065,0.0006273133,0.001049627,0.00005195617,0.00007790937,0.000008114866,0.0001137832,0.000001173249,0.00006360515],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5239735,"threshold_uncertainty_score":0.2906711,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01617779843506987,"score_gpt":0.2499962413941067,"score_spread":0.2338184429590368,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}