{"id":"W3135561905","doi":"10.21203/rs.3.rs-236645/v1","title":"High p16 expression and heterozygous RB1 loss are biomarkers for CDK4/6 inhibitor resistance in ER+ breast cancer","year":2021,"lang":"en","type":"preprint","venue":"Research Square","topic":"Advanced Breast Cancer Therapies","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":false,"ca_institutions":"Institute of Cancer Research","funders":"Congressionally Directed Medical Research Programs; Manchester Biomedical Research Centre; National Institutes of Health; Fundació la Marató de TV3; Fundación Fero; Ipsen; Instituto de Salud Carlos III; Fundació Institut de Recerca Hospital Universitari Vall d’Hebron; Generalitat de Catalunya; Fundación Científica Asociación Española Contra el Cáncer; National Institute for Health and Care Research; Horizon 2020 Framework Programme; Cancer Research UK; Agència de Gestió d'Ajuts Universitaris i de Recerca; Pfizer; Novartis Pharmaceuticals Corporation; Institute for Research in Biomedicine; Centres de Recerca de Catalunya; Genentech; Ministerio de Economía y Competitividad; Memorial Sloan-Kettering Cancer Center; European Commission; Breast Cancer Research Foundation; Eli Lilly and Company","keywords":"Cancer research; Breast cancer; Cancer; Oncology; Expression (computer science); Internal medicine; Medicine; Computer science","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0008700906,0.0005154569,0.001024266,0.0006397599,0.0002328002,0.0001861132,0.0003249291,0.0005706348,0.0002086543],"category_scores_gemma":[0.0003273102,0.0004706622,0.0002069094,0.0005810144,0.0005094906,0.0001909243,0.0009451483,0.001632701,0.000003383334],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001453901,"about_ca_system_score_gemma":0.0009192427,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008652505,"about_ca_topic_score_gemma":0.002172173,"domain_scores_codex":[0.9951159,0.0003863134,0.0005824264,0.001507748,0.00129347,0.001114142],"domain_scores_gemma":[0.9965507,0.0004380825,0.0002425939,0.00110573,0.001236231,0.0004267024],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0890793,0.00347796,0.39643,0.1258828,0.002532511,0.008310337,0.01223755,0.0008794709,0.2089009,0.0004124956,0.01865913,0.1331975],"study_design_scores_gemma":[0.02625863,0.0007145658,0.7082716,0.1608999,0.0001802596,0.0004014283,0.01166651,0.0003384245,0.05254632,0.006380049,0.02950529,0.002837104],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9459575,0.03817394,0.0003168166,0.009049699,0.0005837106,0.003644416,0.00207456,0.0001185754,0.00008076177],"genre_scores_gemma":[0.9879666,0.002792584,0.003920405,0.0001210029,0.00102139,0.002792436,0.0002966045,0.0001685542,0.0009204483],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3118416,"threshold_uncertainty_score":0.9997745,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03926612108891776,"score_gpt":0.3895594867882736,"score_spread":0.3502933656993558,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}