{"id":"W3135561905","doi":"10.21203/rs.3.rs-236645/v1","title":"High p16 expression and heterozygous RB1 loss are biomarkers for CDK4/6 inhibitor resistance in ER+ breast cancer","year":2021,"lang":"en","type":"preprint","venue":"Research Square","topic":"Advanced Breast Cancer Therapies","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":false,"ca_institutions":"Institute of Cancer Research","funders":"Congressionally Directed Medical Research Programs; Manchester Biomedical Research Centre; National Institutes of Health; Fundació la Marató de TV3; Fundación Fero; Ipsen; Instituto de Salud Carlos III; Fundació Institut de Recerca Hospital Universitari Vall d’Hebron; Generalitat de Catalunya; Fundación Científica Asociación Española Contra el Cáncer; National Institute for Health and Care Research; Horizon 2020 Framework Programme; Cancer Research UK; Agència de Gestió d'Ajuts Universitaris i de Recerca; Pfizer; Novartis Pharmaceuticals Corporation; Institute for Research in Biomedicine; Centres de Recerca de Catalunya; Genentech; Ministerio de Economía y Competitividad; Memorial Sloan-Kettering Cancer Center; European Commission; Breast Cancer Research Foundation; Eli Lilly and Company","keywords":"Cancer research; Breast cancer; Cancer; Oncology; Expression (computer science); Internal medicine; Medicine; Computer science","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002958178,0.0003304128,0.0003264408,0.0008140687,0.0001588525,0.0007818606,0.0001774369,0.0004057557,0.004146137],"category_scores_gemma":[0.001299367,0.000242212,0.0001942654,0.0004800164,0.0002221165,0.0002439235,0.0002599048,0.0003850192,0.001157394],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001370447,"about_ca_system_score_gemma":0.000152101,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003429516,"about_ca_topic_score_gemma":0.0002550016,"domain_scores_codex":[0.9998478,0.00002952608,0.00001209865,0.00003191389,0.00005197401,0.00002669897],"domain_scores_gemma":[0.999613,0.00009221546,0.0001475518,0.00004854174,0.00003753703,0.00006119865],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.004741112,0.0002033627,0.7848089,0.0002903362,0.0003394737,0.004359134,0.0002116213,0.001028994,0.1152641,0.001123178,0.00816209,0.07946773],"study_design_scores_gemma":[0.00008086685,0.0003481516,0.9373495,0.00004433463,0.0002091574,0.01690419,0.0002871899,0.001945928,0.03022808,0.003283691,0.00929666,0.00002234913],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9899519,0.001802205,0.001341367,0.0004473974,0.00007478921,0.00001588075,0.001803569,0.0001451394,0.0044178],"genre_scores_gemma":[0.9924018,0.0008611621,0.001205086,0.00007827219,0.00007188984,0.00001338862,0.001876831,0.00005956974,0.003431914],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004146137,"threshold_uncertainty_score":0.01387018,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03926612108891776,"score_gpt":0.3895594867882736,"score_spread":0.3502933656993558,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}