{"id":"W3135562266","doi":"10.2337/dc20-2492","title":"Cardiovascular, Renal, and Metabolic Outcomes of Dapagliflozin Versus Placebo in a Primary Cardiovascular Prevention Cohort: Analyses From DECLARE-TIMI 58","year":2021,"lang":"en","type":"article","venue":"Diabetes Care","topic":"Diabetes Treatment and Management","field":"Medicine","cited_by":37,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; St. Michael's Hospital","funders":"Janssen Research and Development; Daiichi Sankyo Europe; Servier; Eisai; GlaxoSmithKline; IFM Therapeutics; Novo Nordisk; Daiichi-Sankyo; Zora Biosciences; Medicines Company; Intarcia Therapeutics; Ironwood Pharmaceuticals, Incorporated; St. Jude Medical; Regeneron Pharmaceuticals; Boston Scientific Corporation; Bristol-Myers Squibb; Eli Lilly and Company; Allergan; AstraZeneca; CSL Behring; Idorsia Pharmaceuticals; Brigham and Women's Hospital; Sanofi; Esperion Therapeutics; Amgen; Pfizer","keywords":"Dapagliflozin; Medicine; Internal medicine; Hazard ratio; Diabetes mellitus; Placebo; Cohort; Albuminuria; Kidney disease; Blood pressure; Creatinine; TIMI; Type 2 diabetes; Cardiology; Renal function; Endocrinology; Myocardial infarction; Confidence interval; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.005999872,0.001328537,0.002704585,0.0005806864,0.0003764057,0.001093166,0.0007897971,0.001294235,0.002575444],"category_scores_gemma":[0.004736933,0.0007210652,0.005737877,0.0005180481,0.0006921346,0.000648469,0.000897439,0.002295116,0.0003104252],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004675999,"about_ca_system_score_gemma":0.0006628872,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001404876,"about_ca_topic_score_gemma":0.001461833,"domain_scores_codex":[0.9969901,0.001638278,0.0001929458,0.0005366647,0.0002732535,0.0003687801],"domain_scores_gemma":[0.9963357,0.001582271,0.0007684805,0.0006323326,0.000145242,0.0005359295],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.8630406,0.003650324,0.1047906,0.0003434387,0.01625536,0.0001382523,0.0001216311,0.0007844674,0.002581116,0.000105793,0.001100302,0.007088123],"study_design_scores_gemma":[0.1234615,0.1441429,0.6975536,0.00008523804,0.0247669,0.0003379729,0.0002444901,0.005837112,0.00157022,0.0005536216,0.001321918,0.0001244547],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9974564,0.0008931411,0.0002173604,0.00006551591,0.00005698068,0.0001265502,0.0008120437,0.00001610011,0.0003559918],"genre_scores_gemma":[0.9963528,0.0003490821,0.0004446191,0.0001999041,0.0001856043,0.0003840427,0.001458773,0.000007879352,0.0006172489],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005999872,"threshold_uncertainty_score":0.03173077,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02555874830602093,"score_gpt":0.2754049732485506,"score_spread":0.2498462249425296,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}