{"id":"W3135596270","doi":"10.15252/embr.202052255","title":"Increased Alu RNA processing in Alzheimer brains is linked to gene expression changes","year":2021,"lang":"en","type":"article","venue":"EMBO Reports","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":38,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Calgary; University of Lethbridge","funders":"National Institute on Aging; Alberta Prion Research Institute; Canada Research Chairs; Government of Canada; Compute Canada; Genome Canada","keywords":"Gene expression; Biology; RNA; Gene; Rna processing; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00031842,0.0005085304,0.0004016564,0.001647719,0.0004261034,0.0006183049,0.00025727,0.0005134847,0.002157069],"category_scores_gemma":[0.0004386086,0.0003525858,0.0003431333,0.0006702256,0.0004625127,0.0003775872,0.0003365379,0.0007322657,0.0004478863],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001796929,"about_ca_system_score_gemma":0.000139328,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000409612,"about_ca_topic_score_gemma":0.0003803747,"domain_scores_codex":[0.9998062,0.00003070626,0.00002497216,0.00005217486,0.00003897326,0.00004694468],"domain_scores_gemma":[0.9993756,0.00009612311,0.0002626536,0.00006467293,0.00008582247,0.0001151237],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002381272,0.0001135358,0.01167715,0.00006259983,0.00007485141,0.0008923406,0.0001342164,0.00003681855,0.9803508,0.0001581466,0.0001080415,0.004010292],"study_design_scores_gemma":[0.00006655406,0.0008502135,0.4933015,0.00001846357,0.0001819023,0.004754944,0.0004247419,0.0004962073,0.4975637,0.001121247,0.001194027,0.00002649042],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971343,0.0009496712,0.0009096703,0.00006241061,0.00003073023,0.000005859443,0.0002848967,0.00004980731,0.0005724766],"genre_scores_gemma":[0.9958585,0.0006602784,0.001168801,0.00005957508,0.00005839695,0.00002961039,0.0005752847,0.00003348213,0.001556141],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002157069,"threshold_uncertainty_score":0.007216096,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02708510256485074,"score_gpt":0.3096513383534688,"score_spread":0.2825662357886181,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}