{"id":"W3135603479","doi":"10.1097/tp.0000000000003700","title":"An Integrated Clinical and Genetic Prediction Model for Tacrolimus Levels in Pediatric Solid Organ Transplant Recipients","year":2021,"lang":"en","type":"article","venue":"Transplantation","topic":"Renal Transplantation Outcomes and Treatments","field":"Medicine","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta; University of Calgary; Centre Hospitalier Universitaire Sainte-Justine; Alberta Children's Hospital; McGill University Health Centre; University of Toronto; Montreal Children's Hospital; Institut National de la Recherche Scientifique; Hospital for Sick Children; University of British Columbia; University of Alberta Hospital; University Health Network; Health Sciences Centre; SickKids Foundation","funders":"National Center for Advancing Translational Sciences; National Center for Research Resources; Canadian Institutes of Health Research; Canada Research Chairs; National Institutes of Health; Vanderbilt University Medical Center; Heart and Stroke Foundation of Canada; National Heart, Lung, and Blood Institute; Hospital for Sick Children; Astellas Pharma; Vanderbilt University; Burroughs Wellcome Fund","keywords":"Tacrolimus; Dosing; Genotype; Organ transplantation; Transplantation; Pharmacogenetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001540485,0.0001858699,0.0003333371,0.0001515509,0.00006585945,0.00002522102,0.00004191987,0.0001698499,0.00001973262],"category_scores_gemma":[0.00001046485,0.0001664415,0.00008822711,0.0002232623,0.00003147084,0.0001685862,0.000001342755,0.0001565511,0.000003826302],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003123881,"about_ca_system_score_gemma":0.0001641663,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001666144,"about_ca_topic_score_gemma":0.0001982631,"domain_scores_codex":[0.9984384,0.00008733854,0.0006209856,0.000428145,0.0001939972,0.0002311879],"domain_scores_gemma":[0.9993923,0.00009639192,0.00006766828,0.00014816,0.0001228194,0.0001726568],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001543303,0.0005464437,0.9843967,0.00057165,0.00008042435,0.0003637829,0.001681118,0.002892775,0.00276532,0.00004031753,0.00000281411,0.005115331],"study_design_scores_gemma":[0.009787846,0.0003856927,0.9055775,0.0002290774,0.0007009763,0.0003379613,0.0000331058,0.08107134,0.001616952,0.0001201325,0.000003207776,0.0001361821],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8553166,0.00009150525,0.1430473,0.00008907529,0.0001496686,0.0004981164,0.0007240005,0.00005066241,0.00003299617],"genre_scores_gemma":[0.9828164,0.004978676,0.01009261,0.0001500028,0.00008375709,0.000055773,0.001674515,0.00003020894,0.0001180653],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1329547,"threshold_uncertainty_score":0.6787286,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05610456781550594,"score_gpt":0.3615868451890755,"score_spread":0.3054822773735695,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}