{"id":"W3135603479","doi":"10.1097/tp.0000000000003700","title":"An Integrated Clinical and Genetic Prediction Model for Tacrolimus Levels in Pediatric Solid Organ Transplant Recipients","year":2021,"lang":"en","type":"article","venue":"Transplantation","topic":"Renal Transplantation Outcomes and Treatments","field":"Medicine","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta; University of Calgary; Centre Hospitalier Universitaire Sainte-Justine; Alberta Children's Hospital; McGill University Health Centre; University of Toronto; Montreal Children's Hospital; Institut National de la Recherche Scientifique; Hospital for Sick Children; University of British Columbia; University of Alberta Hospital; University Health Network; Health Sciences Centre; SickKids Foundation","funders":"National Center for Advancing Translational Sciences; National Center for Research Resources; Canadian Institutes of Health Research; Canada Research Chairs; National Institutes of Health; Vanderbilt University Medical Center; Heart and Stroke Foundation of Canada; National Heart, Lung, and Blood Institute; Hospital for Sick Children; Astellas Pharma; Vanderbilt University; Burroughs Wellcome Fund","keywords":"Tacrolimus; Dosing; Genotype; Organ transplantation; Transplantation; Pharmacogenetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002952296,0.0009377393,0.001079328,0.00140874,0.0003558616,0.001217729,0.001009454,0.0007352498,0.001817913],"category_scores_gemma":[0.003769582,0.0003423138,0.001256826,0.0007570299,0.0002455717,0.0003733661,0.0007119023,0.001172022,0.0004704646],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007624174,"about_ca_system_score_gemma":0.001475969,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01140826,"about_ca_topic_score_gemma":0.00771708,"domain_scores_codex":[0.9993178,0.0002323113,0.00004396542,0.0002211453,0.00008545481,0.00009940536],"domain_scores_gemma":[0.9977446,0.001455033,0.0002963991,0.00008130734,0.0002636565,0.0001590564],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.001135405,0.0006268151,0.7708845,0.00005530762,0.00116477,0.0004405416,0.0001010461,0.1751553,0.001061374,0.0005411069,0.002727452,0.0461063],"study_design_scores_gemma":[0.0001022974,0.0002321063,0.0762753,0.00002916708,0.0003943219,0.0002190011,0.00004921483,0.9208003,0.0002799037,0.00112094,0.0004751566,0.00002224939],"study_design_candidate":"simulation_or_modeling","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9513385,0.0006619164,0.04282653,0.001058421,0.00005698911,0.00009858317,0.002660714,0.0004043514,0.000894033],"genre_scores_gemma":[0.982645,0.0001813632,0.01305021,0.0001129002,0.00004958448,0.0001187061,0.003189215,0.00002214719,0.0006308951],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01140826,"threshold_uncertainty_score":0.02268374,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05610456781550594,"score_gpt":0.3615868451890755,"score_spread":0.3054822773735695,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}