{"id":"W3135605614","doi":"10.1093/jcag/gwab002.176","title":"A178 USTEKINUMAB FOLLOWING PRIMARY ANTI-TNF FAILURE AND SECONDARY LOSS OF RESPONSE TO VEDOLIZUMAB IN AN ADOLESCENT WITH ULCERATIVE PANCOLITIS","year":2021,"lang":"en","type":"article","venue":"Journal of the Canadian Association of Gastroenterology","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children","funders":"","keywords":"Vedolizumab; Medicine; Infliximab; Ustekinumab; Ulcerative colitis; Internal medicine; Natalizumab; Prednisone; Pancolitis; Calprotectin; Faecal calprotectin; Fingolimod; Adalimumab; Gastroenterology; Inflammatory bowel disease; Immunology; Colonoscopy; Disease; Colorectal cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002488865,0.0002812993,0.000665577,0.0003682244,0.0007569845,0.0005480102,0.0002866509,0.0009900536,0.001199862],"category_scores_gemma":[0.0009361633,0.0001744738,0.0005852389,0.0002564672,0.0003676957,0.0004042525,0.000357235,0.001444544,0.0002834293],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006724992,"about_ca_system_score_gemma":0.0004727489,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001847335,"about_ca_topic_score_gemma":0.002856006,"domain_scores_codex":[0.9997142,0.00004600844,0.00004189712,0.00006457607,0.00005444673,0.00007878578],"domain_scores_gemma":[0.9993414,0.0001184246,0.0001807964,0.00002076423,0.00006119865,0.0002773225],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"case_report","study_design_gemma":"case_report","study_design_scores_codex":[0.0009200499,0.0007254601,0.277176,0.0001991521,0.00008843313,0.6984386,0.001063754,0.0002630495,0.003970257,0.0004323443,0.001452897,0.01527004],"study_design_scores_gemma":[0.0001462935,0.00320691,0.1789809,0.0001589751,0.0001329438,0.809387,0.0009209617,0.0009305233,0.002365698,0.0001979751,0.003551102,0.00002053394],"study_design_candidate":"case_report","study_design_consensus":"case_report","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9959394,0.001177957,0.0002421796,0.0008339076,0.00003749382,0.00003692722,0.0001498105,0.00001291039,0.001569428],"genre_scores_gemma":[0.9986533,0.0003449576,0.0001922512,0.000278104,0.00003369964,0.000009513137,0.00008013536,0.000003617977,0.0004043683],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001847335,"threshold_uncertainty_score":0.004879355,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003637134806723822,"score_gpt":0.2072564899429762,"score_spread":0.2036193551362524,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}