{"id":"W3135606554","doi":"10.21203/rs.3.rs-194964/v1","title":"Racial Differences in the Effect of APOE-ε4 Genotypes on Trail Making Test Part B in Alzheimer’s disease","year":2021,"lang":"en","type":"preprint","venue":"Research Square (Research Square)","topic":"Dementia and Cognitive Impairment Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Clair College","funders":"National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; National Institutes of Health; Genentech; IXICO; H. Lundbeck A/S; Servier; Eisai; Novartis Pharmaceuticals Corporation; BioClinica; U.S. Department of Defense; Meso Scale Diagnostics; Alzheimer's Disease Neuroimaging Initiative; F. Hoffmann-La Roche; Biogen; Eli Lilly and Company; Bristol-Myers Squibb; National Institute on Aging; Alzheimer's Association; Foundation for the National Institutes of Health","keywords":"Disease; Apolipoprotein E; Genotype; Test (biology); Alzheimer's disease; Trail Making Test; Medicine; Psychology; Genetics; Internal medicine; Biology; Cognitive impairment; Ecology; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001791613,0.0002981614,0.0002663793,0.0005584448,0.0003866082,0.0004799306,0.0002514928,0.0003831314,0.001884927],"category_scores_gemma":[0.004965,0.0002010141,0.0006156978,0.0005956914,0.0002500759,0.0003949295,0.0003009682,0.000360774,0.0002474406],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001985243,"about_ca_system_score_gemma":0.0002216073,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00539622,"about_ca_topic_score_gemma":0.005191296,"domain_scores_codex":[0.9991393,0.0003907373,0.00007214918,0.0001830631,0.0001032971,0.0001114712],"domain_scores_gemma":[0.9971659,0.0009087375,0.001051448,0.0002916023,0.0002458459,0.000336579],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001465761,0.0001063558,0.9940245,0.0000100023,0.0002601483,0.00008641942,0.0002016862,0.00007513035,0.0007013982,0.0000774293,0.0001436948,0.002847501],"study_design_scores_gemma":[0.00000851856,0.00009294814,0.9993539,0.000005299442,0.00006543386,0.0000601553,0.0000655721,0.0001271093,0.00008413685,0.00004592152,0.00008821562,0.000002813552],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9988109,0.0003519185,0.0001018242,0.0000493916,0.00001399238,0.000004090572,0.000115375,0.000002346264,0.0005501142],"genre_scores_gemma":[0.9995315,0.00006619692,0.00005561145,0.00001988858,0.000008724283,0.000002740844,0.0001167584,0.000003219856,0.0001952377],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00539622,"threshold_uncertainty_score":0.01072961,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.136155647190647,"score_gpt":0.4595112156866616,"score_spread":0.3233555684960146,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}