{"id":"W3135612624","doi":"10.1093/nar/gkab092","title":"Anti-CRISPR AcrIF9 functions by inducing the CRISPR–Cas complex to bind DNA non-specifically","year":2021,"lang":"en","type":"article","venue":"Nucleic Acids Research","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Canadian Institutes of Health Research; Deutsche Forschungsgemeinschaft","keywords":"CRISPR; Biology; DNA; Nucleic acid; RNA; Mutant; Binding site; Oligonucleotide; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000199668,0.0006846899,0.000335313,0.000229727,0.0001463532,0.0003840645,0.0003679265,0.0004328116,0.001772507],"category_scores_gemma":[0.000161137,0.0002305498,0.0004284839,0.00009715024,0.0002823381,0.0001907821,0.0003551246,0.0006985026,0.0008297442],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003391496,"about_ca_system_score_gemma":0.0001957798,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004564595,"about_ca_topic_score_gemma":0.0007026932,"domain_scores_codex":[0.9996762,0.00003484848,0.00002918065,0.0000795403,0.0001299092,0.00005030917],"domain_scores_gemma":[0.9998031,0.000029102,0.00007439399,0.00003486287,0.00002097322,0.00003753128],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001789063,0.00001136402,0.0001212032,0.00001831858,0.000003732006,0.00002468305,0.000003053744,0.00005695079,0.9989384,0.0000624267,0.00001520825,0.0007268289],"study_design_scores_gemma":[0.000005021284,0.00009480894,0.001723723,0.000002156431,0.000005287503,0.0003333483,0.000005435099,0.0006210033,0.9951806,0.000022895,0.00200209,0.000003621212],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9643232,0.001336483,0.02939602,0.0001087814,0.00007688598,0.00009590184,0.0004588235,0.0005756459,0.003628273],"genre_scores_gemma":[0.9868607,0.000339406,0.00821088,0.00007494247,0.000009529547,0.00004030001,0.0006131008,0.00006922834,0.00378197],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001772507,"threshold_uncertainty_score":0.005929589,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04610761306957226,"score_gpt":0.3808387619525785,"score_spread":0.3347311488830062,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}