{"id":"W3135628855","doi":"10.1016/j.jpeds.2021.03.001","title":"Leukemia Risk in a Cohort of 3.9 Million Children with and without Down Syndrome","year":2021,"lang":"en","type":"article","venue":"The Journal of Pediatrics","topic":"Down syndrome and intellectual disability research","field":"Medicine","cited_by":57,"is_retracted":false,"has_abstract":false,"ca_institutions":"Public Health Ontario; University of Toronto; Institute for Clinical Evaluative Sciences","funders":"Ontario Ministry of Health and Long-Term Care; British Association for American Studies; Mailman School of Public Health, Columbia University; Pediatric Oncology Group of Ontario; National Cancer Institute; Institute for Clinical Evaluative Sciences","keywords":"Medicine; Pediatrics; Down syndrome; Cumulative incidence; Hazard ratio; Incidence (geometry); Leukemia; Cohort; Myeloid leukemia; Retrospective cohort study; Cancer; Internal medicine; Confidence interval","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002349577,0.0002662516,0.0003322034,0.0009775772,0.0006753323,0.0008712802,0.0003703665,0.0006819902,0.001250613],"category_scores_gemma":[0.001005919,0.0004148732,0.0006714647,0.001143208,0.0002554739,0.000550746,0.000574693,0.0008432227,0.0002501121],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000526456,"about_ca_system_score_gemma":0.0005259734,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.03997199,"about_ca_topic_score_gemma":0.0222158,"domain_scores_codex":[0.999742,0.00004608442,0.00002162687,0.00008612018,0.00003306686,0.00007118702],"domain_scores_gemma":[0.9995391,0.00005750158,0.0001505649,0.00003926012,0.0000536657,0.0001599405],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001039254,0.00001943132,0.9988487,0.000002400681,0.0000425173,0.0001353397,0.00008721721,0.00004251284,0.0001850233,0.00002703105,0.0001327754,0.0003731814],"study_design_scores_gemma":[0.000007525781,0.00004896991,0.998531,0.000004703306,0.00003482961,0.0005057449,0.000355629,0.0001404301,0.00004354228,0.00003075816,0.0002920388,0.000004815746],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9982769,0.0001424236,0.00004343603,0.00007811748,0.00000611251,0.000002936335,0.001187465,0.000003694873,0.0002590022],"genre_scores_gemma":[0.9979556,0.0002276387,0.00005442222,0.00005453049,0.00001086858,0.000008805266,0.001191692,0.000004131029,0.0004923359],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03997199,"threshold_uncertainty_score":0.07947868,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01399187377644587,"score_gpt":0.2776203686384516,"score_spread":0.2636284948620057,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}