{"id":"W3135629194","doi":"10.1038/s41408-021-00440-4","title":"Relapsed multiple myeloma demonstrates distinct patterns of immune microenvironment and malignant cell-mediated immunosuppression","year":2021,"lang":"en","type":"article","venue":"Blood Cancer Journal","topic":"Multiple Myeloma Research and Treatments","field":"Medicine","cited_by":38,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital; University of Ottawa","funders":"National Cancer Institute; National Institutes of Health; Mayo Clinic","keywords":"Immune system; Immunology; Multiple myeloma; Immunosurveillance; Tumor microenvironment; Immunotherapy; Cancer research; Biology; Immunosuppression; Stem cell; Medicine; Cell biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000144662,0.0001403473,0.0002352897,0.0005707257,0.000216248,0.0003006476,0.0001154582,0.0001675755,0.0007099119],"category_scores_gemma":[0.0002370632,0.0001067332,0.000120426,0.000426151,0.0002114131,0.000112899,0.0002661097,0.0002171337,0.0001652226],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001968698,"about_ca_system_score_gemma":0.0001062303,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005869883,"about_ca_topic_score_gemma":0.0008206227,"domain_scores_codex":[0.999824,0.00002941414,0.00001345332,0.00005305529,0.0000392219,0.00004089599],"domain_scores_gemma":[0.9998344,0.00002148238,0.00006347131,0.00002700447,0.00001939543,0.00003412705],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001199428,0.00007657779,0.2636699,0.00005313684,0.0000596826,0.0009383706,0.0003985779,0.0001760398,0.7222182,0.0001342507,0.0001139718,0.01096188],"study_design_scores_gemma":[0.00001539612,0.0003688988,0.9735284,0.000004056572,0.00002551267,0.00298252,0.0001721438,0.0002868905,0.02197313,0.00009028152,0.0005473115,0.000005392845],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9993154,0.0002530866,0.0001608246,0.000006507721,9.911564e-7,0.000004799376,0.00006199459,0.000007657336,0.0001887673],"genre_scores_gemma":[0.9995604,0.00005942033,0.0001537498,0.0000106066,0.00000303064,0.000006202336,0.0001087075,0.000002637011,0.00009519841],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007099119,"threshold_uncertainty_score":0.002374947,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01219157137028142,"score_gpt":0.2555898192621097,"score_spread":0.2433982478918283,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}