{"id":"W3135634171","doi":"10.1038/s41467-021-21800-5","title":"Endogenous aldehyde accumulation generates genotoxicity and exhaled biomarkers in esophageal adenocarcinoma","year":2021,"lang":"en","type":"article","venue":"Nature Communications","topic":"Advanced Chemical Sensor Technologies","field":"Engineering","cited_by":42,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Medical Research Council; Queen's University; University Hospitals Coventry and Warwickshire NHS Trust; University of Nottingham; Rosetrees Trust; University of Oxford; National Institute for Health and Care Research; Queen's University Belfast; University of Cambridge; Cancer Research UK; University Hospitals Plymouth NHS Trust; University Hospitals Birmingham NHS Foundation Trust; University College London; Imperial College London; Cambridge University Hospitals; Nottingham University Hospitals NHS Trust; King's College London; University Hospital Southampton NHS Foundation Trust; Wellcome Trust","keywords":"Decanal; Aldehyde; Detoxification (alternative medicine); Endogeny; Genotoxicity; Chemistry; Carcinogen; Pharmacology; Aldehyde dehydrogenase; Biology; Biochemistry; Toxicity; Medicine; Gene; Internal medicine; Pathology; Food science","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001526086,0.000267246,0.0002059173,0.0003364626,0.00009251627,0.0002660156,0.0001086108,0.0002769328,0.0006246571],"category_scores_gemma":[0.0001749764,0.0001214018,0.000227544,0.0002038081,0.0001607091,0.000225182,0.0002671377,0.0002154384,0.0001422942],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002113614,"about_ca_system_score_gemma":0.00008905706,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003213572,"about_ca_topic_score_gemma":0.0004457333,"domain_scores_codex":[0.9998813,0.00003523791,0.000009542092,0.00002508199,0.00002915459,0.00001960934],"domain_scores_gemma":[0.9999137,0.00001528814,0.00002964298,0.000009932988,0.00001313139,0.00001825586],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005464956,0.00003417929,0.00689928,0.00005137196,0.00001993451,0.0001695801,0.00002217388,0.0001368322,0.9895051,0.00002993221,0.00001999948,0.002565099],"study_design_scores_gemma":[0.00001578551,0.001182534,0.08168829,0.0000111475,0.00006937832,0.00112063,0.0001235957,0.001553444,0.913115,0.0001572288,0.0009531854,0.000009849121],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9962766,0.001965402,0.00136569,0.00003949832,0.000009995249,0.000008251827,0.0001038371,0.00001673276,0.0002139933],"genre_scores_gemma":[0.9980491,0.0006996419,0.0006814569,0.00002823499,0.000005279245,0.00001002069,0.0001511103,0.000003792285,0.0003713255],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006246571,"threshold_uncertainty_score":0.002089679,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04097664990657397,"score_gpt":0.2839732060562862,"score_spread":0.2429965561497123,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}