{"id":"W3135634171","doi":"10.1038/s41467-021-21800-5","title":"Endogenous aldehyde accumulation generates genotoxicity and exhaled biomarkers in esophageal adenocarcinoma","year":2021,"lang":"en","type":"article","venue":"Nature Communications","topic":"Advanced Chemical Sensor Technologies","field":"Engineering","cited_by":42,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Medical Research Council; Queen's University; University Hospitals Coventry and Warwickshire NHS Trust; University of Nottingham; Rosetrees Trust; University of Oxford; National Institute for Health and Care Research; Queen's University Belfast; University of Cambridge; Cancer Research UK; University Hospitals Plymouth NHS Trust; University Hospitals Birmingham NHS Foundation Trust; University College London; Imperial College London; Cambridge University Hospitals; Nottingham University Hospitals NHS Trust; King's College London; University Hospital Southampton NHS Foundation Trust; Wellcome Trust","keywords":"Decanal; Aldehyde; Detoxification (alternative medicine); Endogeny; Genotoxicity; Chemistry; Carcinogen; Pharmacology; Aldehyde dehydrogenase; Biology; Biochemistry; Toxicity; Medicine; Gene; Internal medicine; Pathology; Food science","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000355484,0.0001239709,0.0001387894,0.00008371965,0.00008997883,0.00002455852,0.0003741544,0.0003175802,0.000007969407],"category_scores_gemma":[0.0001919112,0.0001385003,0.00002727407,0.0004063285,0.00009348357,0.0001015778,0.0001631113,0.0006683987,0.000003661085],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000108989,"about_ca_system_score_gemma":0.000007075313,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00000644954,"about_ca_topic_score_gemma":0.0001787093,"domain_scores_codex":[0.999368,0.00003750851,0.0001809391,0.0001612992,0.000074622,0.0001776346],"domain_scores_gemma":[0.9987811,0.0002038643,0.00002475527,0.000900622,0.00005241761,0.00003718792],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000003385107,0.00003935225,0.01736704,0.00002071887,0.0000619392,0.00002229672,0.0001164602,0.002298649,0.9748776,0.001632768,0.00009392054,0.003465896],"study_design_scores_gemma":[0.0003988048,0.000006703345,0.04606844,0.00002049768,0.00002281566,0.00006750898,0.0001203483,0.02226033,0.9279648,0.001632964,0.00117284,0.0002639482],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8997199,0.09809998,0.0001851871,0.0004657879,0.00004020497,0.0001496808,0.00001947975,0.0004510779,0.0008687171],"genre_scores_gemma":[0.9779428,0.00239811,0.01943857,0.00005672683,0.00001451359,0.00002980028,0.0000899818,0.00002158219,0.0000079446],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09570188,"threshold_uncertainty_score":0.5647877,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04097664990657397,"score_gpt":0.2839732060562862,"score_spread":0.2429965561497123,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}