{"id":"W3135636541","doi":"10.1101/2021.03.03.433580","title":"Neuronal ROS-Induced Glial Lipid Droplet Formation is Altered by Loss of Alzheimer’s Disease-associated Genes","year":2021,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Lipid metabolism and biosynthesis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Intellectual and Developmental Disabilities Research Center; National Institutes of Health; University of Alberta; Canadian Institutes of Health Research; Alzheimer Society; Howard Hughes Medical Institute","keywords":"ABCA1; LRP1; Endocytic cycle; Retromer; Cell biology; Biology; Astrogliosis; Neurodegeneration; Gene; Neuroscience; Endosome; Genetics; Disease; Cell; Endocytosis; Biochemistry; Transporter; Lipoprotein; Central nervous system; LDL receptor; Cholesterol; Internal medicine; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009038712,0.0002117828,0.0001827964,0.0003530814,0.0001278568,0.0002401272,0.0000954871,0.0001492846,0.001427807],"category_scores_gemma":[0.0001017161,0.0001003201,0.0001897219,0.0001643007,0.0001403715,0.00009733132,0.0002305843,0.0002772369,0.000555835],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002159025,"about_ca_system_score_gemma":0.0001057593,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007492637,"about_ca_topic_score_gemma":0.0008341208,"domain_scores_codex":[0.9999278,0.000008078126,0.000007547558,0.00001660812,0.00002629835,0.00001370272],"domain_scores_gemma":[0.9999254,0.000009494148,0.00002425826,0.0000127679,0.00001175568,0.0000162773],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009461547,0.000008936463,0.0009466385,0.00001756065,0.000007433528,0.0001555758,0.00001719517,0.00003938638,0.9973555,0.0001084863,0.00008365176,0.001165078],"study_design_scores_gemma":[0.0000159576,0.00006039234,0.03425188,0.000008494471,0.00002104741,0.001105829,0.00007925489,0.0007672271,0.9585711,0.000303363,0.004809838,0.000005568118],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9942616,0.0006330737,0.002388222,0.0001074586,0.00003047822,0.000008144794,0.0008612604,0.0001116124,0.001598209],"genre_scores_gemma":[0.9902653,0.0006813328,0.00289455,0.00005126318,0.000009139603,0.00002002899,0.001385356,0.00008881674,0.004604429],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001427807,"threshold_uncertainty_score":0.004776478,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01508688914582,"score_gpt":0.220426312731396,"score_spread":0.205339423585576,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}