{"id":"W3135653814","doi":"10.1093/jcag/gwab002.228","title":"A230 ISOMALTODEXTRIN DOSE-DEPENDENTLY REDUCES COLITIS DEVELOPMENT IN HLA-B27 RAT COLITIS MODEL WITH ASSOCIATED CHANGES TO GUT MICROBIOME COMPOSITION AND SHORT CHAIN FATTY ACID PRODUCTION","year":2021,"lang":"en","type":"article","venue":"Journal of the Canadian Association of Gastroenterology","topic":"Gut microbiota and health","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Dysbiosis; Colitis; Short-chain fatty acid; Gut flora; Cecum; Prebiotic; Inflammatory bowel disease; Microbiome; Bacteroides; Inulin; Metabolome; Biology; Bifidobacterium; Calprotectin; Microbiology; Butyrate; Internal medicine; Food science; Immunology; Biochemistry; Medicine; Bacteria; Lactobacillus; Fermentation; Metabolite; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001485842,0.0005288208,0.0006259698,0.000726714,0.0001684854,0.0002312788,0.0002768496,0.0004117376,0.00232633],"category_scores_gemma":[0.0001221748,0.0002218655,0.0003683926,0.0002674724,0.0003177308,0.000299541,0.0001972354,0.001206888,0.0004161968],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001963852,"about_ca_system_score_gemma":0.0003464225,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000683895,"about_ca_topic_score_gemma":0.001043199,"domain_scores_codex":[0.9998291,0.00002268871,0.00002042901,0.0000349661,0.00003874065,0.00005415754],"domain_scores_gemma":[0.9997396,0.00001647329,0.00006242043,0.00002269482,0.00003493044,0.0001238093],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.005136939,0.002575438,0.0007503745,0.0001902069,0.00004240716,0.0000789758,0.00004125979,0.0001418178,0.985684,0.00005963112,0.0002932231,0.005005606],"study_design_scores_gemma":[0.0005214383,0.02980641,0.01288085,0.00005208222,0.0001636535,0.0002190194,0.0001811623,0.001091455,0.9512259,0.000118804,0.00370771,0.00003158784],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9954355,0.001454242,0.0008756336,0.0001659268,0.00009549501,0.0000816707,0.0006343035,0.0001852837,0.001071885],"genre_scores_gemma":[0.9874384,0.001887459,0.002081859,0.0001624437,0.00003774543,0.0002405986,0.0009149292,0.0000331409,0.00720339],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00232633,"threshold_uncertainty_score":0.0077824,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009162157504429462,"score_gpt":0.2231725563127134,"score_spread":0.2140103988082839,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}