{"id":"W3135673850","doi":"10.3390/cancers13051002","title":"Apoptotic Blocks in Primary Non-Hodgkin B Cell Lymphomas Identified by BH3 Profiling","year":2021,"lang":"en","type":"article","venue":"Cancers","topic":"Chronic Lymphocytic Leukemia Research","field":"Medicine","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Hôpital Maisonneuve-Rosemont; Spinal Cord Injury BC; McGill University; Jewish General Hospital","funders":"Canadian Institutes of Health Research","keywords":"Venetoclax; MCL1; Vincristine; Mantle cell lymphoma; Cancer research; Apoptosis; Lymphoma; Chronic lymphocytic leukemia; Doxorubicin; B cell; Follicular lymphoma; Medicine; Chemistry; Biology; Chemotherapy; Leukemia; Immunology; Internal medicine; Antibody; Downregulation and upregulation; Cyclophosphamide; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001557014,0.000125835,0.0001910981,0.0004753388,0.0001588163,0.0002070438,0.000116816,0.0001279896,0.001164178],"category_scores_gemma":[0.0002083566,0.00008606727,0.0001261372,0.0002826343,0.000157523,0.00008920427,0.0001308944,0.0002036533,0.000281703],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002132278,"about_ca_system_score_gemma":0.00009218172,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001244445,"about_ca_topic_score_gemma":0.002201137,"domain_scores_codex":[0.9998179,0.00002734288,0.00001366625,0.00002922216,0.00005144118,0.00006037472],"domain_scores_gemma":[0.9998602,0.00004031056,0.0000247833,0.00001803453,0.00003588045,0.00002076678],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000273839,0.00002920454,0.004624759,0.00003220336,0.000007316867,0.0001082643,0.00003886769,0.000042372,0.9917549,0.00001497126,0.00003191116,0.003041419],"study_design_scores_gemma":[0.00004186969,0.0009429611,0.1758023,0.000008152876,0.00006461045,0.001707205,0.0001495297,0.0009078627,0.8182138,0.0000504641,0.002106219,0.00000503365],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9974205,0.0008815628,0.0007382509,0.00001529346,0.000002722413,0.0000258638,0.0002486829,0.00003344066,0.0006336031],"genre_scores_gemma":[0.9973304,0.0003848139,0.0009084754,0.00002778258,0.000004474897,0.00002728224,0.0006688511,0.000009564892,0.0006383439],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001244445,"threshold_uncertainty_score":0.003894508,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01231629058363107,"score_gpt":0.2777437701108712,"score_spread":0.2654274795272401,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}