{"id":"W3135673850","doi":"10.3390/cancers13051002","title":"Apoptotic Blocks in Primary Non-Hodgkin B Cell Lymphomas Identified by BH3 Profiling","year":2021,"lang":"en","type":"article","venue":"Cancers","topic":"Chronic Lymphocytic Leukemia Research","field":"Medicine","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Hôpital Maisonneuve-Rosemont; Spinal Cord Injury BC; McGill University; Jewish General Hospital","funders":"Canadian Institutes of Health Research","keywords":"Venetoclax; MCL1; Vincristine; Mantle cell lymphoma; Cancer research; Apoptosis; Lymphoma; Chronic lymphocytic leukemia; Doxorubicin; B cell; Follicular lymphoma; Medicine; Chemistry; Biology; Chemotherapy; Leukemia; Immunology; Internal medicine; Antibody; Downregulation and upregulation; Cyclophosphamide; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002946942,0.0001954066,0.0004122039,0.0001271508,0.00005482862,0.00004014965,0.00017368,0.0001575235,0.0004339641],"category_scores_gemma":[0.0001279345,0.0001998463,0.0001030318,0.0006324687,0.0001191959,0.00008341984,0.0001324602,0.0003079838,0.00009429437],"about_ca_system_candidate":true,"about_ca_system_consensus":true,"about_ca_system_score_codex":0.09087525,"about_ca_system_score_gemma":0.04420866,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001448749,"about_ca_topic_score_gemma":0.00008573862,"domain_scores_codex":[0.9978051,0.00005354032,0.0003725212,0.000563734,0.0005709238,0.0006342099],"domain_scores_gemma":[0.9988814,0.0001162285,0.00006769696,0.0005569545,0.0001315819,0.000246136],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001075782,0.0002714896,0.006772616,0.003705418,0.0002341147,0.004978343,0.001916501,0.002532813,0.8702534,0.00005082592,0.09826285,0.00994583],"study_design_scores_gemma":[0.03408928,0.0001462463,0.001125392,0.000643328,0.0001015663,0.0002356478,0.001028108,0.02354276,0.9304348,0.00005615172,0.008128137,0.000468603],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9582002,0.003071163,0.00009174088,0.000173865,0.0004021421,0.0005212047,0.00001330714,0.00005146984,0.03747492],"genre_scores_gemma":[0.9789736,0.000369409,0.0006306311,0.0007953576,0.0001872151,0.00009571938,0.0001371979,0.00005418831,0.01875667],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09013471,"threshold_uncertainty_score":0.9612098,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01231629058363107,"score_gpt":0.2777437701108712,"score_spread":0.2654274795272401,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}