{"id":"W3135711232","doi":"10.1039/d1ra00788b","title":"New protein tyrosine phosphatase inhibitors from fungus <i>Aspergillus gorakhpurensis</i> F07ZB1707","year":2021,"lang":"en","type":"article","venue":"RSC Advances","topic":"Protein Tyrosine Phosphatases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"Horizon 2020 Framework Programme; Hebei Medical University; Hebei University; Natural Science Foundation of Hebei Province","keywords":"HeLa; Xanthone; Chemistry; IC50; Stereochemistry; Cytotoxicity; Fungus; Two-dimensional nuclear magnetic resonance spectroscopy; In vitro; Aspergillus; Enzyme; Aspergillus nidulans; Protein tyrosine phosphatase; Phosphatase; Biochemistry; Biology; Microbiology; Botany","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.00008051818,0.0003643697,0.000315772,0.00002934603,0.0001351093,0.00007400096,0.0003052732,0.0001781791,0.0002872619],"category_scores_gemma":[0.0003157982,0.0003624156,0.0001487661,0.0002723502,0.0001029424,0.00003304624,0.0003172038,0.0001574002,0.0001029568],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003876434,"about_ca_system_score_gemma":0.0003659956,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002534012,"about_ca_topic_score_gemma":0.0002898113,"domain_scores_codex":[0.9979481,0.00007096354,0.000372156,0.000848278,0.0002997625,0.0004608167],"domain_scores_gemma":[0.9985818,0.00002259101,0.0001704432,0.0008020506,0.0001560132,0.0002670611],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002669946,0.0000998285,0.0005861248,0.00003826623,0.00009057825,0.0001672154,0.00002111017,0.0001259471,0.9031363,0.001714187,0.03716035,0.05659306],"study_design_scores_gemma":[0.0006332928,0.0001007045,0.000109529,0.00005519066,0.00002190179,0.00001165469,0.00002447615,0.000003623824,0.6294012,0.000752039,0.3685936,0.0002927772],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.09706439,0.8898814,0.00769027,0.0009481573,0.001083085,0.0007363211,0.001628027,0.0001397991,0.0008285102],"genre_scores_gemma":[0.9108354,0.005171455,0.06482761,0.001934042,0.003310536,0.0001655923,0.007900834,0.0001726597,0.005681895],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.88471,"threshold_uncertainty_score":0.9998828,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006314700700747013,"score_gpt":0.2326052617495447,"score_spread":0.2262905610487977,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}