{"id":"W3135711232","doi":"10.1039/d1ra00788b","title":"New protein tyrosine phosphatase inhibitors from fungus <i>Aspergillus gorakhpurensis</i> F07ZB1707","year":2021,"lang":"en","type":"article","venue":"RSC Advances","topic":"Protein Tyrosine Phosphatases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"Horizon 2020 Framework Programme; Hebei Medical University; Hebei University; Natural Science Foundation of Hebei Province","keywords":"HeLa; Xanthone; Chemistry; IC50; Stereochemistry; Cytotoxicity; Fungus; Two-dimensional nuclear magnetic resonance spectroscopy; In vitro; Aspergillus; Enzyme; Aspergillus nidulans; Protein tyrosine phosphatase; Phosphatase; Biochemistry; Biology; Microbiology; Botany","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006495101,0.000551559,0.0002954677,0.0003059075,0.000120096,0.000166179,0.0001905523,0.0001536664,0.001024463],"category_scores_gemma":[0.00006023335,0.00009814656,0.000240428,0.0002020443,0.0001084669,0.0001167507,0.0001911267,0.0003592762,0.0004067427],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001221619,"about_ca_system_score_gemma":0.0001980867,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005706265,"about_ca_topic_score_gemma":0.001273848,"domain_scores_codex":[0.9999571,0.000005186004,0.000004254344,0.00000664612,0.00001478181,0.00001199675],"domain_scores_gemma":[0.9999684,0.000004726794,0.000006246083,0.000001849454,0.000006764881,0.00001203705],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001134194,0.00004020935,0.0001883711,0.0001574581,0.00001732846,0.0001746883,0.00001232583,0.000259406,0.9863021,0.0001600804,0.0002881736,0.01228638],"study_design_scores_gemma":[0.0001381301,0.001471133,0.006010897,0.00003761245,0.00008693511,0.00112341,0.00003826362,0.000618378,0.9737489,0.0001470594,0.01655592,0.00002336471],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9640563,0.01567451,0.007639793,0.0002540308,0.0001222662,0.0002061894,0.001940632,0.0003055658,0.009800721],"genre_scores_gemma":[0.978032,0.008096305,0.006210873,0.0002201264,0.00003420913,0.0001022957,0.003383593,0.00003302849,0.003887607],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001024463,"threshold_uncertainty_score":0.003427148,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006314700700747013,"score_gpt":0.2326052617495447,"score_spread":0.2262905610487977,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}