{"id":"W3135805738","doi":"10.1073/pnas.2003014118","title":"Adaptation of pancreatic cancer cells to nutrient deprivation is reversible and requires glutamine synthetase stabilization by mTORC1","year":2021,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Pancreatic and Hepatic Oncology Research","field":"Medicine","cited_by":54,"is_retracted":false,"has_abstract":true,"ca_institutions":"FujiFilm VisualSonics (Canada)","funders":"National Cancer Institute; National Center for Research Resources; Boston Children's Hospital; American Cancer Society","keywords":"mTORC1; Adaptation (eye); Glutamine; Pancreatic cancer; Nutrient; Cancer; Glutamine synthetase; Biochemistry; Chemistry; Biology; Internal medicine; Amino acid; Medicine; Ecology; Neuroscience; Phosphorylation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007528826,0.0001637777,0.0002240151,0.0001084544,0.0001662647,0.0004083577,0.0001164969,0.0001228169,0.0007780515],"category_scores_gemma":[0.00009497447,0.00009427912,0.0001597725,0.0001319189,0.0001510429,0.0001019454,0.0002621501,0.0003193649,0.0002519786],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002222961,"about_ca_system_score_gemma":0.0001973281,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004177022,"about_ca_topic_score_gemma":0.001219933,"domain_scores_codex":[0.9999162,0.000009915589,0.000008486253,0.00002359904,0.00002598845,0.00001588443],"domain_scores_gemma":[0.9999443,0.000008807606,0.00001589446,0.00001035974,0.000007193715,0.00001347878],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005298594,0.00001143565,0.0006477266,0.00001809201,0.000005076087,0.00005888783,0.000009232564,0.00006229131,0.9968785,0.00005865998,0.00005185723,0.002145121],"study_design_scores_gemma":[0.000009842011,0.0002139823,0.02485368,0.000005484511,0.00001348429,0.0006402579,0.00005287117,0.0006701257,0.968751,0.00004722859,0.004736301,0.000005782213],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9936057,0.001551041,0.001924954,0.0001092609,0.00001928751,0.00002182304,0.0004628931,0.0001017133,0.002203281],"genre_scores_gemma":[0.995027,0.0009138158,0.001413258,0.00005572526,0.000006990703,0.0000259489,0.0005931265,0.00002538113,0.001938774],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007780515,"threshold_uncertainty_score":0.002602816,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06100070621306522,"score_gpt":0.354379149643668,"score_spread":0.2933784434306027,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}