{"id":"W3135812366","doi":"10.1128/msystems.00233-21","title":"Identification and Development of Therapeutics for COVID-19","year":2021,"lang":"en","type":"article","venue":"mSystems","topic":"Pharmacological Receptor Mechanisms and Effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"Carleton University","funders":"National Human Genome Research Institute; National Institutes of Health; Gordon and Betty Moore Foundation; National Heart, Lung, and Blood Institute; Fast Grants; National Institute of General Medical Sciences; American Heart Association","keywords":"Middle East respiratory syndrome; Identification (biology); Coronavirus; Middle East respiratory syndrome coronavirus; Adaptation (eye); Disease; Coronavirus disease 2019 (COVID-19); Pandemic","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001857187,0.00004270079,0.00006664056,0.000007126292,0.00004243691,0.000007806017,0.00003567271,0.00005291885,0.000006103906],"category_scores_gemma":[0.00005299536,0.0000369718,0.00001910872,0.00002082121,0.00001111329,6.335191e-7,0.00002492723,0.00001199605,9.888407e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000008649173,"about_ca_system_score_gemma":0.0000950102,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":7.632628e-7,"about_ca_topic_score_gemma":0.000004249338,"domain_scores_codex":[0.9996157,0.00002931455,0.0001196089,0.0001265245,0.00004248999,0.00006635435],"domain_scores_gemma":[0.9997742,0.00001713646,0.00004714367,0.00006850604,0.00004490608,0.00004817255],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001580272,0.00001969258,0.0001120394,0.0001136319,0.00002832918,2.617495e-7,0.00006005101,0.000005090169,0.9956229,0.0001531681,0.0002463133,0.003622729],"study_design_scores_gemma":[0.0002405332,0.00003575729,0.0001014139,0.000003371951,0.000006304784,0.000002740244,0.00006079416,0.00005998847,0.8065811,0.00003862758,0.1928288,0.00004053803],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.877218,0.001421579,0.1207084,0.0001004489,0.0002327486,0.0002434044,0.00001285066,0.00000598627,0.00005660536],"genre_scores_gemma":[0.9982517,0.00005247652,0.001014978,0.0002629954,0.00004505938,0.00005004599,0.00004938072,0.000004514841,0.000268849],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1925825,"threshold_uncertainty_score":0.1507666,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05121288281819442,"score_gpt":0.342347994864383,"score_spread":0.2911351120461886,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}