{"id":"W3135826314","doi":"10.1182/blood.2020007683","title":"Characterization of DLBCL with a PMBL gene expression signature","year":2021,"lang":"en","type":"article","venue":"Blood","topic":"Lymphoma Diagnosis and Treatment","field":"Medicine","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; Simon Fraser University; Spinal Cord Injury BC; University of British Columbia","funders":"Terry Fox Research Institute; Genome British Columbia; Michael Smith Health Research BC; BC Cancer Foundation; Canadian Institutes of Health Research; Genome Canada","keywords":"Lymphoma; Germinal center; Diffuse large B-cell lymphoma; Pathology; Bone marrow; Biology; Large-cell lymphoma; Reed–Sternberg cell; Gene signature; BCL6; Cancer research; B cell; Medicine; Gene; Gene expression; Immunology; Genetics; Antibody; Hodgkin lymphoma","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001950073,0.0001635322,0.0001908277,0.0008293047,0.0001519023,0.0003083436,0.0001214191,0.0001781177,0.0006581988],"category_scores_gemma":[0.0003514902,0.00008043242,0.0001179615,0.0005198838,0.0002082326,0.000167405,0.0002752151,0.0001628831,0.0002210641],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001401251,"about_ca_system_score_gemma":0.00007271962,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003191148,"about_ca_topic_score_gemma":0.0004713938,"domain_scores_codex":[0.9998491,0.00001882933,0.00001805925,0.00003895676,0.00003937798,0.00003567313],"domain_scores_gemma":[0.9997838,0.00004342466,0.00006460415,0.00002011333,0.00003641963,0.00005153611],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0003690003,0.00003342351,0.6106337,0.00008125472,0.00002945196,0.002314832,0.0002126381,0.0001130199,0.3755241,0.00008364204,0.0001237328,0.01048118],"study_design_scores_gemma":[0.00002153544,0.0002328426,0.9518935,0.0000149559,0.0000479318,0.01878565,0.0004225812,0.001290239,0.0250416,0.0001441099,0.002098261,0.000006774746],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9989723,0.0002815838,0.000269074,0.00001312352,0.000001389447,0.000006796794,0.000161276,0.000007298435,0.0002871118],"genre_scores_gemma":[0.9988576,0.0001373201,0.0004389303,0.00001571431,0.000004253429,0.00000815129,0.0004364611,0.000002772345,0.00009873277],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008293047,"threshold_uncertainty_score":0.002201855,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007000797437366479,"score_gpt":0.2135871744456708,"score_spread":0.2065863770083043,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}