{"id":"W3135840271","doi":"10.1038/s41467-021-21644-z","title":"Epidermal growth factor receptor signaling uncouples germ cells from the somatic follicular compartment at ovulation","year":2021,"lang":"en","type":"article","venue":"Nature Communications","topic":"Reproductive Biology and Fertility","field":"Medicine","cited_by":84,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; McGill University Health Centre; McGill University; University Health Network","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; China Scholarship Council; McGill University Health Centre; Faculty of Medicine, McGill University; McGill University","keywords":"Cell biology; Somatic cell; Oocyte; Biology; Filopodia; Ovulation; Epidermal growth factor; Ovarian follicle; Follicular phase; Endocrinology; Receptor; Genetics; Hormone; Embryo; Actin","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002398475,0.0001322352,0.0002428093,0.00001925651,0.0004992558,0.00001642327,0.0003350292,0.0002382668,0.0002890972],"category_scores_gemma":[0.0005868207,0.00009095492,0.0001354755,0.0001805692,0.0001786083,0.00005780032,0.0002665019,0.0006828964,0.00007480092],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001412595,"about_ca_system_score_gemma":0.00009378141,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003445788,"about_ca_topic_score_gemma":0.0001625005,"domain_scores_codex":[0.9986773,0.0004403696,0.0002885535,0.0002805411,0.0001683715,0.00014485],"domain_scores_gemma":[0.9964971,0.001001499,0.000127978,0.001992526,0.0003183674,0.00006256518],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0002358885,0.0005776573,0.2502717,0.00003129775,0.0004733381,0.00000446895,0.001342428,0.00002129915,0.7377488,0.00144965,0.007236888,0.0006065664],"study_design_scores_gemma":[0.0004457446,0.00002249837,0.7875756,0.00005780895,0.000151576,0.000006143632,0.0001940952,0.0003708075,0.177674,0.0006326754,0.03274577,0.0001232368],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9586511,0.01909028,0.0001512428,0.020904,0.0002823718,0.0004266985,0.000102891,0.00005993552,0.0003315047],"genre_scores_gemma":[0.9918702,0.0004121181,0.004993448,0.001068786,0.000154796,0.00003936172,0.001293574,0.00001156889,0.0001561543],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5600748,"threshold_uncertainty_score":0.3839923,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04343616209326338,"score_gpt":0.311637450429859,"score_spread":0.2682012883365956,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}