{"id":"W3135908836","doi":"10.1016/j.drudis.2021.02.025","title":"Recent development in the design of small ‘drug-like’ and nanoscale glycomimetics against Escherichia coli infections","year":2021,"lang":"en","type":"review","venue":"Drug Discovery Today","topic":"Carbohydrate Chemistry and Synthesis","field":"Chemistry","cited_by":21,"is_retracted":false,"has_abstract":false,"ca_institutions":"Institut National de la Recherche Scientifique; Université du Québec à Montréal","funders":"Fonds de recherche du Québec – Nature et technologies; Natural Sciences and Engineering Research Council of Canada","keywords":"Glycoconjugate; Escherichia coli; Antibiotics; Drug; Drug resistance; Chemistry; Microbiology; Computational biology; Biology; Combinatorial chemistry; Biochemistry; Pharmacology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0005830042,0.0005682781,0.001429157,0.0000801613,0.0001395256,0.0001553731,0.0004731,0.0003128574,0.0001285259],"category_scores_gemma":[0.0002198185,0.0004320618,0.0003249016,0.0005384377,0.0001404194,0.00008324331,0.0002417605,0.0006188492,0.000006511932],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002425594,"about_ca_system_score_gemma":0.0008762642,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002261511,"about_ca_topic_score_gemma":0.00005425025,"domain_scores_codex":[0.9975308,0.0002569103,0.0009681605,0.0005875287,0.0002874823,0.0003691688],"domain_scores_gemma":[0.9974751,0.00122727,0.0004258172,0.0007213384,0.00006411782,0.00008631243],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00003785898,0.002104078,0.0001026209,0.03565656,0.001097983,0.0001824866,0.003657293,0.0001716117,0.005584457,0.00009858028,0.004339402,0.9469671],"study_design_scores_gemma":[0.0001869411,0.000003730882,0.000001654551,0.008389112,0.0003760657,0.00001487957,0.0004386902,0.00001361131,0.01472468,0.000009366825,0.9753195,0.0005217453],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.01259825,0.9831036,0.00005022978,0.00005208729,0.0001797893,0.0003673654,0.0001086959,0.00002498569,0.003515007],"genre_scores_gemma":[0.0004501757,0.9960167,0.0003295738,0.00005460237,0.00008306166,0.0002799401,0.0003751234,0.00005837831,0.002352463],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9709801,"threshold_uncertainty_score":0.9998131,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03764073329489653,"score_gpt":0.2603883492187103,"score_spread":0.2227476159238138,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}