{"id":"W3135952602","doi":"10.3390/cancers13061296","title":"Candidate Markers of Olaparib Response from Genomic Data Analyses of Human Cancer Cell Lines","year":2021,"lang":"en","type":"article","venue":"Cancers","topic":"PARP inhibition in cancer therapy","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre; Jewish General Hospital; Université de Montréal; Centre Hospitalier de l’Université de Montréal; McGill University; McGill Genome Centre","funders":"","keywords":"Olaparib; PARP inhibitor; Synthetic lethality; Cancer research; Biology; Medicine; Genetics; DNA repair; Gene; Poly ADP ribose polymerase","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003903383,0.0002395729,0.0004144567,0.0009415276,0.0001626015,0.0003742295,0.0001684311,0.0001681074,0.001099891],"category_scores_gemma":[0.001367474,0.00006912275,0.0002053824,0.001244635,0.0001530728,0.0001094503,0.0002256903,0.000211148,0.0002339421],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000195444,"about_ca_system_score_gemma":0.0001951651,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000907346,"about_ca_topic_score_gemma":0.001763823,"domain_scores_codex":[0.9996093,0.0000871557,0.00005258961,0.0001142426,0.00009508411,0.0000417212],"domain_scores_gemma":[0.9990488,0.0004726105,0.0002053607,0.0001027354,0.0001351888,0.00003540771],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001359137,0.0001946859,0.3060322,0.0004542798,0.0003452861,0.0005445188,0.0001950628,0.003585567,0.6470927,0.0001640241,0.0009047414,0.03912794],"study_design_scores_gemma":[0.00004015906,0.0004735724,0.8717407,0.00002188695,0.0002498957,0.001458856,0.0001945225,0.007131449,0.1139401,0.0002375624,0.004486878,0.00002448094],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9854269,0.0007265347,0.004047768,0.00006354219,0.000005631327,0.00006095753,0.009047844,0.00009999307,0.0005207337],"genre_scores_gemma":[0.963814,0.0004558293,0.005960315,0.00008866502,0.00001003805,0.0001737824,0.02913371,0.00002578826,0.0003379093],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001099891,"threshold_uncertainty_score":0.003679454,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1123597604053039,"score_gpt":0.4141688062111543,"score_spread":0.3018090458058504,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}