{"id":"W3135955177","doi":"10.1158/2159-8290.cd-20-1066","title":"ZFTA–RELA Dictates Oncogenic Transcriptional Programs to Drive Aggressive Supratentorial Ependymoma","year":2021,"lang":"en","type":"article","venue":"Cancer Discovery","topic":"Genomics and Chromatin Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":90,"is_retracted":false,"has_abstract":true,"ca_institutions":"Jewish General Hospital; McGill Genome Centre; McGill University; McGill-Queen's University Press","funders":"National Institute of Neurological Disorders and Stroke; National Institute of General Medical Sciences; Cancer Prevention and Research Institute of Texas; Natural Sciences and Engineering Research Council of Canada; Adrienne Helis Malvin Medical Research Foundation; Rally Foundation; National Cancer Institute; National Institutes of Health; Cancer Research UK; Hyundai Hope On Wheels; Canadian Institutes of Health Research; Alex's Lemonade Stand Foundation for Childhood Cancer","keywords":"Biology; Ependymoma; Chromatin immunoprecipitation; Chromatin; Cancer research; Genetics; Epigenomics; Gene; Cell biology; Computational biology; Gene expression; DNA methylation; Promoter; Pathology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009731054,0.0002591874,0.0001283226,0.0002517819,0.0001265766,0.0001980503,0.0001828747,0.0001571239,0.001325123],"category_scores_gemma":[0.00007954366,0.0001013392,0.0001757201,0.000104785,0.0002261004,0.0001584849,0.0002310634,0.0004431746,0.0002896122],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003311381,"about_ca_system_score_gemma":0.0001623129,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005439765,"about_ca_topic_score_gemma":0.001513876,"domain_scores_codex":[0.999915,0.000004725378,0.000006898938,0.00002358221,0.00002316323,0.00002666761],"domain_scores_gemma":[0.999923,0.00001029525,0.0000312349,0.000007254463,0.000005748234,0.0000224954],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002230807,0.00001014209,0.0004721232,0.00001090169,0.000002596511,0.00007540744,0.000006973486,0.00004044921,0.9985636,0.00009628327,0.00002148511,0.0006777951],"study_design_scores_gemma":[0.00001405204,0.0002387978,0.02011742,0.000005202624,0.00001322913,0.0007054658,0.00006329739,0.0008203338,0.9760725,0.00006746589,0.001878522,0.000003649067],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9962953,0.0003497617,0.002029471,0.0000368899,0.000009806595,0.00001685901,0.0003374067,0.00008875407,0.0008356045],"genre_scores_gemma":[0.9968385,0.000181832,0.001222725,0.00002032403,0.000003476299,0.00001499009,0.0002964181,0.00001365682,0.001408105],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001325123,"threshold_uncertainty_score":0.004432976,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009226579239951198,"score_gpt":0.2481065064729971,"score_spread":0.2388799272330459,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}