{"id":"W3135967114","doi":"10.1016/s2666-5247(21)00010-0","title":"Long-term effects of early antiretroviral initiation on HIV reservoir markers: a longitudinal analysis of the MERLIN clinical study","year":2021,"lang":"en","type":"article","venue":"The Lancet Microbe","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":71,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Centre Hospitalier de l’Université de Montréal","funders":"National Institute of Allergy and Infectious Diseases; National Institute on Drug Abuse; Canadian Institutes of Health Research; Université de Montréal; Agència de Gestió d'Ajuts Universitaris i de Recerca; National Institutes of Health; Generalitat de Catalunya; Fred Hutchinson Cancer Research Center; Gilead Sciences; Merck","keywords":"Human immunodeficiency virus (HIV); Term (time); Merlin (protein); Medicine; Antiretroviral therapy; Virology; Biology; Immunology; Viral load; Internal medicine; Physics; Cancer","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00402613,0.0003867054,0.0004181981,0.0006630196,0.000563764,0.0007494611,0.0004756149,0.0005347471,0.001111193],"category_scores_gemma":[0.005017116,0.0004221156,0.0005357828,0.0007685024,0.0002792402,0.0007335809,0.0009011861,0.0006884981,0.0002211499],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004765854,"about_ca_system_score_gemma":0.0004335906,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003768101,"about_ca_topic_score_gemma":0.005079316,"domain_scores_codex":[0.9985543,0.0008850725,0.00006737676,0.0002221707,0.00009692533,0.000174141],"domain_scores_gemma":[0.9966682,0.000607302,0.001529913,0.0004177829,0.0003575041,0.0004193638],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001138228,0.00007356581,0.9962896,0.00001803429,0.0001439964,0.00008785149,0.0002483763,0.00003177116,0.0002865656,0.00002572414,0.000175912,0.001480442],"study_design_scores_gemma":[0.00005076535,0.0005062671,0.998275,0.00001707394,0.0001088165,0.000139858,0.0002329932,0.0002273935,0.000066554,0.00002427784,0.0003438294,0.000007130338],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9985843,0.0004852679,0.0001519727,0.000076248,0.000003638071,0.00002577471,0.0004324581,0.000004572682,0.0002357499],"genre_scores_gemma":[0.9989057,0.0001246724,0.000221311,0.00003965686,0.00000944024,0.00004528758,0.0004683859,0.000004443415,0.0001811218],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00402613,"threshold_uncertainty_score":0.02129245,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04802829748343899,"score_gpt":0.3477037699578884,"score_spread":0.2996754724744494,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}