{"id":"W3135981208","doi":"10.1038/s41467-021-21867-0","title":"CRISPRi screens reveal a DNA methylation-mediated 3D genome dependent causal mechanism in prostate cancer","year":2021,"lang":"en","type":"article","venue":"Nature Communications","topic":"Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities","field":"Biochemistry, Genetics and Molecular Biology","cited_by":65,"is_retracted":false,"has_abstract":true,"ca_institutions":"Vancouver General Hospital; University of British Columbia; Vector Institute; Ontario Institute for Cancer Research; University Health Network; University of Toronto; Princess Margaret Cancer Centre","funders":"National Institute of General Medical Sciences; Canadian Institutes of Health Research; Terry Fox Research Institute; Fudan University; National Natural Science Foundation of China; National Institute of Diabetes and Digestive and Kidney Diseases; Prostate Cancer Canada; National Cancer Institute; National Institutes of Health; Jane ja Aatos Erkon Säätiö; Ontario Institute for Cancer Research; Natural Sciences and Engineering Research Council of Canada; Princess Margaret Cancer Foundation","keywords":"CTCF; DNA methylation; Biology; Epigenetics; Genetics; Single-nucleotide polymorphism; Carcinogenesis; Computational biology; Locus (genetics); Epigenomics; Enhancer; Transcription factor; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002180216,0.0004022913,0.0003150582,0.000421564,0.0002352773,0.0004533709,0.0003638467,0.0004700407,0.003181904],"category_scores_gemma":[0.0003038713,0.000279294,0.0004221154,0.000219318,0.0003005178,0.0001009442,0.0006477797,0.0007247909,0.0005880248],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003432107,"about_ca_system_score_gemma":0.0002973069,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001267125,"about_ca_topic_score_gemma":0.004040911,"domain_scores_codex":[0.9997577,0.00003359042,0.0000170366,0.00006233739,0.00008998439,0.00003931449],"domain_scores_gemma":[0.9998153,0.00006377956,0.00005361734,0.00002646244,0.00001029299,0.00003066276],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008373919,0.00002345894,0.001786267,0.00007968806,0.00004677548,0.0004109749,0.0000370087,0.001097524,0.9884689,0.0008011856,0.0002232065,0.006941223],"study_design_scores_gemma":[0.00004310261,0.0003667665,0.03302385,0.00003984952,0.0001701827,0.002475568,0.00008989731,0.0128629,0.9319315,0.00113275,0.01781175,0.00005186316],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9214755,0.001404836,0.06208292,0.0004285436,0.00009979995,0.0001497539,0.004352895,0.002835849,0.007169863],"genre_scores_gemma":[0.9806867,0.0004810036,0.01450293,0.0001825712,0.000007642624,0.00004690376,0.0009420294,0.0001529114,0.002997413],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003181904,"threshold_uncertainty_score":0.01064456,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01565187867080554,"score_gpt":0.3076724072654244,"score_spread":0.2920205285946189,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}