{"id":"W3136017577","doi":"10.1182/blood.2020008551","title":"Very long chain fatty acid metabolism is required in acute myeloid leukemia","year":2021,"lang":"en","type":"article","venue":"Blood","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":114,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; Western University; Population Health Research Institute; Ontario Institute for Cancer Research; University of Waterloo; University of Guelph","funders":"National Institute of Diabetes and Digestive and Kidney Diseases","keywords":"Citric acid cycle; Biology; Beta oxidation; Glycolysis; Oxidative phosphorylation; Myeloid leukemia; Myeloid; Leukemia; Haematopoiesis; Fatty acid metabolism; Metabolism; Biochemistry; Cancer research; Cell biology; Stem cell; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002137654,0.0002124664,0.0003868658,0.0006398366,0.0002437824,0.0007291395,0.0001682072,0.0002360984,0.001188103],"category_scores_gemma":[0.0007023418,0.0001041037,0.0002066519,0.001326122,0.0001403296,0.0003906351,0.0004350262,0.0002593411,0.0004891199],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003353987,"about_ca_system_score_gemma":0.0002799007,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008585975,"about_ca_topic_score_gemma":0.001363162,"domain_scores_codex":[0.9996579,0.00004435188,0.00005346711,0.00008524307,0.0001151803,0.00004376954],"domain_scores_gemma":[0.9995798,0.00006904302,0.0002242109,0.00004197575,0.00003662995,0.00004827473],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001449881,0.00006202305,0.04436891,0.0004987741,0.0001096471,0.0006436412,0.00006955188,0.000959669,0.9226175,0.0005692492,0.001032372,0.02761872],"study_design_scores_gemma":[0.00009241018,0.0005373494,0.4247099,0.0001785107,0.0002930288,0.004167373,0.0003763953,0.008056472,0.5255291,0.002301176,0.03368869,0.00006950399],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9813651,0.002937064,0.003025053,0.0001955942,0.00001674702,0.00001897755,0.01090303,0.0002936066,0.001244717],"genre_scores_gemma":[0.9767942,0.001403009,0.003663956,0.0001012645,0.00001099511,0.00002382861,0.01737654,0.0000243313,0.0006018424],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001188103,"threshold_uncertainty_score":0.003974617,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01949441641062023,"score_gpt":0.2833962493196377,"score_spread":0.2639018329090175,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}