{"id":"W3136028360","doi":"10.1242/jcs.252411","title":"Rab5 regulates macropinocytosis by recruiting the inositol 5-phosphatases OCRL and Inpp5b that hydrolyse PtdIns(4,5)P2","year":2021,"lang":"en","type":"article","venue":"Journal of Cell Science","topic":"Cellular transport and secretion","field":"Biochemistry, Genetics and Molecular Biology","cited_by":36,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Michael's Hospital; SickKids Foundation; University of Toronto; Ontario Medical Association; Hospital for Sick Children","funders":"Canadian Institutes of Health Research; Ariad Pharmaceuticals; Heart and Stroke Foundation of Canada; Pfizer","keywords":"Pinocytosis; Biology; Cell biology; Phosphatidylinositol; Membrane ruffling; Vesicle; Internalization; Lipid bilayer fusion; Inositol; Phosphatase; Biochemistry; Kinase; Endocytosis; Phosphorylation; Membrane; Cell; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004966825,0.00009705588,0.0001209546,0.00003250816,0.0002412242,0.0001082129,0.0002676329,0.00005559107,0.00002156409],"category_scores_gemma":[0.00005315508,0.00006728174,0.00007366648,0.0001884686,0.0003023143,0.000025531,0.00007427137,0.0001211587,8.298515e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001306592,"about_ca_system_score_gemma":0.0001523733,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000008380325,"about_ca_topic_score_gemma":0.000008225987,"domain_scores_codex":[0.9990343,0.00003776171,0.0002235044,0.0002005934,0.0003069345,0.0001968734],"domain_scores_gemma":[0.9993338,0.000021364,0.0002044367,0.0001772819,0.0001536394,0.0001094652],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002455607,0.00002482074,0.004831463,0.000009350108,0.00000849337,0.00001959622,0.0001134154,0.000009397547,0.9932015,0.000008492469,0.0005073427,0.00124156],"study_design_scores_gemma":[0.000258654,0.00009196116,0.001978394,0.00002640341,0.00002634423,0.000140951,0.0002662862,0.00005980663,0.9623353,0.00003942658,0.03468646,0.00008997016],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9878308,0.01011674,0.0009343631,0.0005425648,0.0001860151,0.0000487009,0.000007508901,0.00000216337,0.0003311433],"genre_scores_gemma":[0.9961184,0.002753731,0.0004188668,0.0002269441,0.0001211515,8.57075e-7,0.00004354902,0.000006300935,0.0003102168],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03417912,"threshold_uncertainty_score":0.274367,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01026643355795413,"score_gpt":0.2285396626629692,"score_spread":0.218273229105015,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}